Targeting Trends
Ta rgeting Topics: Recent Scientific References(continued from page 3)Selective immunolesioning of the basal
of the same cognitive deficits exhibited by
expressing neurons to the determination of a
forebrain cholinergic neurons in rats:
rats lesioned with 192-Saporin (Cat. #IT-01),
effect on attention using the 5-choice
which eliminates cholinergic cells in the
p75NTR-expressing neurons are not essential
serial reaction time task.
basal forebrain. The results suggest that in
this Down syndrome model, cell loss has a
much greater cognitive effect if it happens
Rivastigmine antagonizes deficits in Psychopharmacology 164:71-81, 2002
prepulse inhibition induced by
The authors used 0.067 µg injections of 192-
selective immunolesioning of
Saporin (Cat. #IT-01) into the nucleus basalis
cholinergic neurons in nucleus basalis
magnocellularis to investigate attentional
magnocellularis.
exhibited a very specific subset of attentional
difficulty completing tasks in the presence ofdistractions.
The authors injected 300 nl of 400 ng/µl192-Saporin (Cat. #IT-01) bilaterally into the
Spinal neurons that possess the
nucleus basalis magnocellularis of rats, then
substance P receptor are required for the development of central
rivastigmine, a cholinesterase inhibitor. sensitization.
Animals treated with rivistagmine exhibited
raised levels of cortical acetylcholine, in
contrast to undetectable acetylcholine levels
in lesioned animals not treated withrivastigmine.
Using 5 x 10 -5 M intrathecal injections ofSP-SAP (Cat. #IT-07) the authors examined
Mnemonic deficits in animals depend upon the degree of cholinergic deficit
modulation of pain and hyperalgesia. Treated
and task complexity. Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons.
Bechade C, Mallecourt C, Sedel F, Vyas S,
In this study, the authors compared icv and
intraparenchymal injections of 192-Saporin
In vivo labeling of rabbit cholinergic
respectively). While a similar reduction in
In the rat, half of motoneurons die between
basal forebrain neurons with
embryonic day 15 and postnatal day 1. fluorochromated antibodies.
Programmed cell death of interneurons is not
performance in certain allocentric tasks was
as well characterized. The authors cultured
similar, an egocentric task showed a marked
explants of brachial neural tubes from rat
NeuroReport 13(11):1395-1398, 2002
To investigate in vivo labeling of p75 low-
affinity neurotrophin receptor the authors
Saporin had no direct effect on interneurons
in culture, elimination of p75-neurotrophin
and performed either unilateral or bilateral
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demonstrating its potential as a p75 marker. Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 Reactivity to object and spatial neurotrophin receptors, calbindin- New Products, novelty is normal in older Ts65Dn D28K, and light-induced Fos in the mice that model Down syndrome and suprachiasmatic nucleus in rats. Latest News Alzheimer’s disease. Place Your Orders!
The authors used bilateral icv injections of
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LUBOMBO SDI- MALARIA CONTROL PROGRAMME Author: Dr Brian Sharp FUNDER : BUSINESS TRUST Abstract The Lubombo Spatial Development Initiative (LSDI) malaria control programme was officially inaugurated by the 3 country, ministerial signing of a protocol of agreement, during October 1999. The geographic area targeted by this initiative is broadly defined as Eastern Swaziland, Southe