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CRUK CI Annual International Symposium 2013 Ralph DeBerardinisChildren’s Medical Center Research Institute at UT Southwestern Introduction of the Chair by Kevin Brindle Ralph DeBerardinisUT SouthwesternCancer metabolism – basic biology and translational approaches John GriffithsCancer Research UK Cambridge InstituteImaging metabolism: Carbonic anhydrase IX acts as the tumour extracellular pH and links the Warburg effect with Robert GilliesMoffitt Cancer CenterTargeting hypoxia in pancreatic cancer Selected talk from submitted abstracts Tiago RodriguesCancer Research UK Cambridge InstituteMagnetic resonance imaging of tumour glycolysis using hyperpolarized 13C-labelled glucose Markus SchwaigerTechnische Universität MünchenMetabolic biomarkers in cancer Sarah NelsonUniversity of California, San Francisco1H and 13C MR metabolic imaging of cancer patients 12.25–13.10 “Unanswered Questions” panel discussion introduced by Lunch and poster session (S1, 2, 4: 13.10-14.00, S3: 14.00-14.50) CRUK CI Annual International Symposium 2013 Adrian HarrisUniversity of OxfordInduced essentiality of hypoxic metabolism provides new ways to enhance antiangiogenic therapy Randall JohnsonUniversity of CambridgeThe relationship between hypoxic response, HIF isoforms, and metastatic success Navdeep ChandelNorthwestern UniversityMitochondria ROS regulate cancer Selected talk from submitted abstracts Ming YangUniversity of OxfordThe emerging role of fumarate as an oncometabolite Michael LisantiUniversity of ManchesterTwo-compartment tumour metabolism: Implications for personalised cancer diagnosis and therapy Richard MithenInstitute of Food ResearchRe-tuning metabolism to reduce risk of cancer progression “Unanswered Questions” panel discussion introduced by Buffet dinner at the CRUK Cambridge Institute CRUK CI Annual International Symposium 2013 Light breakfast at the CRUK Cambridge Institute Introduction of the Chair by Christian Frezza Eytan RuppinTel Aviv UniversityGenome scale modelling of cancer metabolism Eyal GottliebCancer Research UK Beatson InstituteMetabolic networks in fumarate hydratase-deficient cancer Joshua RabinowitzPrinceton UniversityNADPH in cancer metabolism Selected talk from submitted abstracts Paolo PorporatoUniversity of Louvain, BelgiumA mitochondrial switch promotes tumor metastasis Almut SchulzeCancer Research UK London Research InstituteMetabolic reprogramming in cancer supports cell growth and survival Markus RalserUniversity of CambridgeFrom early origins of metabolism to the dynamics of metabolic networks in modern organisms 12.50–13.35 “Unanswered Questions” panel discussion introduced by CRUK CI Annual International Symposium 2013 Lewis CantleyWeill Cornell Medical College Introduction of the Chair by Masashi Narita Lewis CantleyWeill Cornell Medical CollegePI3K and cancer metabolism Matthew Vander HeidenKoch InstituteRegulation of metabolism to support cancer growth and progression William KaelinHarvard UniversityThe von Hippel-Lindau tumor suppressor protein: Insights into oxygen sensing and cancer metabolism Selected talk from submitted abstracts Thorsten CramerCharité, BerlinFunctional integrity of tumor-specific glutamine metabolism is determined by a novel interaction of HIF-1 and Annexin A1 Chi Van DangUniversity of PennsylvaniaTargeting Myc-mediated cancer metabolism Clemens SchmittMax-Delbrück-Center for Molecular MedicineExploiting senescence-associated hypermetabolism as a cancer vulnerability “Unanswered Questions” panel discussion introduced by Lewis CantleyWeill Cornell Medical College Announcement of poster prize winners and symposium close Symposium reception at Jesus College; dinner at 19.30

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