Pediatric Allergic Rhinitis: Antihistamine Selection Introduction
As the most common of mediated inflammation of the are not serious and do not endan-
Allergic Rhinitis and Children
19 years.5,8 As with adults, the im-pact of AR in children extends be-yond the immediate symptomsand has a profound effect on chil-dren’s QoL, the extent of which
Allergy/Asthma Associates, Mission Viejo, California.
the severity of disease.9 Trouble-some, repeated nose blowing, fa-
This paper was supported by an educational grant from Aventis Pharmaceuticals. Reprint requests and correspondence to: William E. Berger, MD, Allergy/Asthma Associates,
27800 Medical Center Road, 244 Mission Viejo, CA 92691.
2005 Westminster Publications, Inc., 708 Glen Cove Avenue, Glen Head, NY 11545, U.S.A. Older-Generation Antihistamines A n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i s
cost, availability, and advertisingplay a significant role in deter-
mining which antihistamine achild receives. MAXIMUM RECOMMENDED DAILY DOSES FOR AVAILABLE SECOND-GENERATION ANTIHISTAMINES FOR CHILDREN WITH SAR Newer-Generation Antihistamines
Loratadine rapidly disintegrating tablets
avoiding the adverse events (AEs)obser ved with older agents. Al-though these agents are credited
Cetirizine (Zyrtec®) tablets (5 mg, 10 mg)
Cetirizine (Zyrtec®) syrup (5 mL [2.5mg])
gous. Therefore, each agentshould be judged separately interms of relative efficacy and
60 mg (30 mg BID) (children 6–11 yrof age)
safety. To date, three oral newer-generation antihistamines areavailable for use in children in the
gra® [Aventis Pharm.], indicatedfor use in children aged 6 yearsand older), loratadine (Claritin®[Schering-Plough], 2 years orolder) and cetirizine (Zyrtec®
Clinical Efficacy and Safety of Newer- Generation Antihistamines in Children
rated ‘good’ or ‘excellent’ in 82%
A n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i sA n t i h i s t a m i n e s a n d A l l e r g i c R h i n i t i sConclusions
with trials of these antihistamines.
a fast onset of action is desirable.
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THE NEW LOW CALORIE SWEETENER OGNEAN Claudia Felicia, DARIE Neli, OGNEAN Mihai “Lucian Blaga” University of Sibiu Abstract: This review summarizes information relate to new low-calorie sweetener: erythritol, difructose anhydride, monellin, mabinlin, pentadin, and stevioside. In addition, important developments in food applications are reported. INTRODUCTION Dietary and health