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Daoud K. Abu-Hamdan, M.D.
Telephone: (313) 576-1000
EDUCATION:

Baccalaureate: Al-Hussein
M.D., Faculty of Medicine, Universidad Complutense, Madrid, Spain, 1968
TRAINING:

1969 - 1973
Medical Officer, Jordanian Royal Medical Service, Jordan Rotating Internship, Base Military Hospital, Amman, Jordan Rotating Medical Intern, Mount Vernon Hospital, Mount Vernon, New York Medical Resident, Mount Vernon Hospital, Mount Vernon, New York Medical Resident, New Rochelle Hospital Medical Center, New Rochelle, New York Nephrology Fellowship, Wayne State University Affiliated Hospitals Program, Detroit, Michigan FACULTY APPOINTMENTS:

1979 - 1990
Assistant Professor of Medicine, Wayne State University School of Medicine, Detroit, Michigan
1990 - Present
Associate Professor of Medicine, Wayne State University School
of Medicine, Detroit, Michigan

HOSPITAL APPOINTMENTS:
1979 - 1990
Staff, Nephrology Section, Medical Service, VA Medical Center, Allen Park, Michigan
1980 - Present
Staff, Department of Medicine, Hutzel Hospital, Detroit, Michigan

1982 - Present
Staff, Department of Medicine, Detroit Receiving Hospital and
University Health Center, Detroit, Michigan

1983 - Present
Staff, Department of Medicine, Harper-Grace Hospitals, Detroit,
Michigan

2005 – Present
Staff, Karmanos cancer hospital, Detroit, Michigan

1990 - Present
Chief, Nephrology Section, Medical Service, VA Medical Center,
Detroit, Michigan

1990 - Present
Chair, End Stage Renal Disease Committee

2005 –Present
Chair, Peer Review Committee, VA Medical Center, Detroit,
Michigan

MAJOR PROFESSIONAL SOCIETIES:

American Federation for Clinical Research
American Society of Nephrology
International Society of Nephrology
American College of Physicians
National Kidney Foundation
American Society of Hypertension
Arab American Medical Association

LICENSURE AND BOARD CERTIFICATION:

Licensure - State of Michigan 1977 - American Board of Internal Medicine 1980 - American Board of Nephrology
SERVICE:
Patient Care:
Tuesday PM:
Renal Clinic/Primary care - VA Medical Center, Detroit, Michigan
Wednesday PM:
Renal Clinic/Primary Care - VA Medical Center, Detroit, Michigan
Thursday AM:
Renal Clinic/Primary Care - VA Medical Center, Detroit, Michigan

Professional Consultation:
Renal Consultations:
Eight months/year at VA Medical Center
9 Weekend coverage of the whole medical center

Hemodialysis Rounding:
Eight months/year at VA Medical Center

Internal Medicine Ward Rounds:
ONE month/year at VA Medical Center

TEACHING:
July 1979 - Present
Courses taught at Wayne State University in last five years.
Participated in teaching Nephrology seminars for
sophomore students ten hours/yearly.
Renal Pathophysiology Lecture Year II students (1 hour)
Professor’s round with nephrology fellows (one hour every
4 months).
Basic Science Lecture for nephrology section (one
hour/year)
GRANT SUPPORT:
1988 - 1990
Ross Laboratories (Co-Investigator). Effect of a dietary protein modification on the progress of chronic renal failure, $396,110. VA Merit Review (Co-Investigator). Gonadal Dysfunction in Men with Uremia, $59,000. NIH (Co-Investigator). Gonadal Dysfunction in Chronic Renal Failure, $196,000. Wyeth-Ayerst Laboratories (Co-Investigator).A pharmacodynamic and pharmacokinetics study of intravenously administered reconstituted depolymerized heparin in normal subjects and in patients with chronic renal insufficiency, $158,101. Merck Cozaar Study #C0Z345 (Co-Investigator). A prospective, double-blind, randomized comparison of two treatment regimens: Cozaar and Hyzaar versus Procardia XL in the treatment of elderly patients with mild-to-moderate hypertension, $13,000. Bristol-Myers Squibb (Principle Investigator). Factorial trial of the efficacy and safety of multiple dosages of SR47436 (Bristol-Myers Squibb - 186295) and HCTZ in mild-to-moderate hypertension. Bristol-Myers Squibb (Co-Investigator). Multi-center, randomized, double-blind, lisinopril placebo controlled trial of the antihypertensive efficacy and safety of omapatrilat in black subjects with mild to moderate hypertension. VA Cooperative Study #440 (Principle Investigator). Anti-Thrombotic Agents In The Prevention Of Hemodialysis Access Thrombosis, Cost $85,620.00 Merck LIFE Study #133-00/COZ368 (Principle Investigator). Losartan intervention for endpoint reduction in hypertension. A Study evaluating the Initiation of Fixed Doses of Novel Erythropoiesis Stimulating Protein (NESP) Therapy in Subjects with Chronic Renal Insufficiency (CRI) $15,000.00 yearly.(PI)
2001 - 2007
VA Cooperative Study #453 (Principal Investigator).
Homocysteinemia in Kidney and End Stage Renal Disease Study
(HOST). $70,000.00

2002 - 2003
VA CSP#453 HOST-DNA. Genetic Tissue Banking for the HOST study (PI) $3000.00 VA Cooperative Studies Programs # 476. Enhancing Quality of Informed consent-Development Phase (EQUIC-DP). (PI) $3000.00
2004 -2005
(Amgen) Darbepoeitin alfa study 20030237. (PI) $3300.00

GRANT PROPOSALS (Submitted in the past)

1982
NIH, (Co-Investigator). "Intestinal and Renal Zinc Transport: Role of Diet, Parahormone and Vitamin D", (approved, not funded). NIH, (Co-Investigator). "Intestinal and Renal Zinc Transport", (approved, not funded).
PUBLICATIONS:
Original Observations in Refereed Journals

1. Migdal, S.D., Slick, G.L., Abu-Hamdan, D.K., and McDonald, F.D.: Phenytoin, renal
function and renin release. J Pharma Exp Thera 215:304-306, 1980.
2. Mahajan, S.K., Carey, E., Kinhal, V., Abu-Hamdan, D.K., Briggs, W.A., and McDonald,
F.D.: Effect of correction of dialysis related hypoxemia on cardiac dysfunction during hemodialysis. Clin Dial Transplant Forum 10:110-113, 1980.
3. Abu-Hamdan, D.K., Migdal, S.D., Whitehouse, R., Prasad, A.S., and McDonald, F.D.:
Renal handling of zinc: Effect of cysteine infusion. Amer J Phys 241:F487-494, 1981.
4. Mahajan, S.K., Abraham, J., Bornstein, K., Hessberg, T., Migdal, S.D., Abu-Hamdan,
D.K., Prasad, A.S., Briggs, W.A. and McDonald, F.D.: Zinc metabolism and taste
acuity in renal transplant recipients. Kidney Int 24(16):S310-314, 1983.

5. Abu-Hamdan, D.K., Desai, S., Mahajan, S., Mueller, B., Briggs, W., Lynne-Davies, L.,
and McDonald, F.: Hypoxemia during hemodialysis using acetate versus bicarbonate dialysis. Am J Nephrology 4:248-253, 1984.
6. Mahajan, S.K., Abraham, J., Migdal, S.D., Abu-Hamdan, D.K., and McDonald, F.D.:
Effect of renal transplantation on zinc metabolism and taste acuity in uremia: A prospective study. Transplantation 38:6, 599-602, 1984.
7. Mahajan, S.K., Speck, J.A., Varghese, G.A., Abu-Hamdan, D.K., Migdal, S.D., Prasad,
A.S., and McDonald, F.D.: Zinc metabolism in nephrotic syndrome. Nutrition Research, Supplement 1, pp. 360-362, 1985.
8. Abu-Hamdan, D.K., Mahajan, S.K., Migdal, S.D., Prasad, A.S., and McDonald, F.D.:
Zinc tolerance test in uremia: Effect of ferrous sulfate and aluminum hydroxide. Ann Int Med 104:50-52, 1986.
9. Sondheimer, J.H., Mahajan, S.K., Rye, D.L., Abu-Hamdan, D.K., Migdal, S.D.,
Prasad, A.S., and McDonald, F.D.: Elevated plasma copper levels in uremia. Am J Clin Nutr 47:896-899, 1988. 10. Abu-Hamdan, D.K., Mahajan, S.K., Migdal, S.D., Prasad, A.S., and McDonald, F.D.:
Zinc tolerance test in uremia: Effect of calcitriol supplementation. J Am Coll Nutr 7:235-240, 1988. 11. Abu-Hamdan, D.K., Desai, H., Sondheimer, J., Felicetta, J., Mahajan, S., and
McDonald, F: Taste acuity and zinc metabolism in Captopril-treated hypertensive male patients. Am J Hypertension 1:303s-308s, 1988. 12. Mahajan, S.K., Bowersox, E., Rye, D.L., Abu-Hamdan, D.K., McDonald, F.D., Prasad,
A.S., Biersack, K.: Factors underlying abnormal zinc metabolism in uremia. Kidney Int 36:318-323, 1989. 13. Kozol, R., Wilson, R.F., Mahajan, S., Abu-Hamdan, D.K., and Thomas, D.: Gastric
Intramural Acidosis in patients with chronic renal failure. Surgery 113; 520-526, 1993.
Published Review Articles

1. D.K. Abu-Hamdan., J.R. Sowers. Diabetes, Dyslipidemia, and Renal Disease in the
Elderly. Council on geriatric cardiology. February 1998, pp 60-64.
Original Observations Published in Book Form

1. Ganji, S., Mahajan, S., Abu-Hamdan, D.K., and Migdal, S.: Somatosensory evoked
potential in uremia. Progress in Artificial Organs, 1983. K. Atusumi, M. Mackawa, and K. Ota (editors), ISAO Press, Cleveland, 1984, Vol 1, pp.436-438.
2. Mahajan, S.K., Migdal, S.D., Port, F.D., Rye, D.L., Abraham, J., Abu-Hamdan, D.K.,
and McDonald, F.D.: Hypozincemia in patients undergoing CAPD. Advances in Continuous Ambulatory Peritoneal Dialysis, R. Khanna, et al (editors). University of Toronto Press, 1986, pp.65-69.
3. Mahajan, S.K., Rye, D.L., Rifat, S., Weissler, J., Abu-Hamdan, D.K., and McDonald,
F.D.: Hypercupremia in uremia: The role of artificial kidneys. Blood Purification in Perspective: New Insight and Future Trends. N.K. Man, et al (editors). ISAO Press, Cleveland, 1987, pp.63-66.
Case Reports in Refereed Journals:

1. 18. Abu-Hamdan, D.K., Sondheimer, J.H. and Mahajan, S.K.: Cautopyreiophagia: A
cause of life threatening hyperkalemia in a hemodialysis patient. Am J Med 79:517-519, 1985.
Review in Patient Education Publication:

1. Abu-Hamdan, D.K., McDonald, F.D.: Zinc and Sexuality in renal failure. NKF Family
1. BjÖrn DahlÖf, Devereux RB Hans Wedel for the life study group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE) a randomized trial against atenolol. The Lancet: 359 pp: 995-1003, 2002. (D Abu-Hamdan named in appendix among primary investigators).
2. Kaufman JS, O’Connor TZ, Zhang JH et al for the Veteran Affairs Cooperative
Study Group on Hemodialysis Access graft thrombosis. Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis. J Am Soc Nephrol. 2003 Sep; 14(9):2313-21. (D Abu Hamdan named in appendix among primary investigators)
3. Rex L. Jamison, Pamela Hartigan, J Michael Gaziano et al. Design and
statistical issues in the homocysteinemia in kidney and end stage renal
disease (HOST) study. Clinical trials 2004; 1: 451-460. (Daoud K Abu-Hamdan
named in appendix among primary investigators)

PUBLISHED ABSTRACTS

1. Abu-Hamdan, D.K., Desai, H., Sondheimer, J., Felicetta, J., Mahajan, S., and
McDonald, F.: Effects of Captopril on zinc status and taste acuity in hypertensive male patients. Kidney Int 31:294A, 1987.
2. Wood, M., Mahajan, S., Sillix, D., Abu-Hamdan, D.K., Migdal, S., and McDonald, F.:
Zinc metabolism and taste acuity in Cyclosporine-Prednisone treated renal transplant recipients. Kidney Int 31:361A, 1987.
3. Mahajan, S., Sillix, D., Wood, M., Bhat, S., Martin, J., Abu-Hamdan, D.K., Migdal, S.,
and McDonald, F.: Lack of Post-transplant hypophosphatemia in Cyclosporine-Prednisone treated renal transplant recipients. Kidney Int 31:463A, 1987.
4. Abu-Hamdan, D.K., Desai, H., Sondheimer, J., Felicetta, J., Mahajan, S., and
McDonald, F.: Taste Acuity and Zinc (Zn) Metabolism in Captopril-treated hypertensive male patients. Clin Res 35:437A, 1987.
5. Mahajan, S., Bowersox, E., Rye, D., Abu-Hamdan, D.K., Biersack, K., McDonald, F.,
and Prasad, A.: Zinc balance studies in uremia. Clin Res 36:868A, 1988.
6. Migdal, S.D., Mutchnick, M.G., Mahajan, S.K., Abu-Hamdan, D.K., and McDonald,
F.D.: Serum Thymosin B (TB) levels in patients chronic renal failure. Kidney Int 35:399, 1989.
7. Mahajan, S., Wang, H., Abu-Hamdan, D.K., McDonald F. and Prasad, A.: Plasma and
Cellular zinc in uremia. Kidney Int 35:399, 1989. 8. Khoury, S., Mahajan, S., Abu-Hamdan, D.K., and Joshi, N.: The pattern of LH
secretion and responsiveness to pulsatile GnRH in men with uremia. Clin Res 37:896, 1989.
9. Mahajan, S., Prasad, A., Abu-Hamdan, D.K., Bowersox, L., McDonald, F., and
Biersack, K.: Effect of vitamin D on zinc metabolism in uremia. Clin Res 37:932, 1989. 10. Mahajan, S., Prasad, A., Abu-Hamdan, D.K., and Joshi, N.: Gonadal dysfunction in
uremia: Luteinizing Hormone secretion and its responsiveness to gonadotrophin releasing hormone. Kidney Int 37:276, 1990. 11. Mahajan, S., Abu-Hamdan, D.K., Prasad, A., Bowersox, L., McDonald, F., and
Biersack, K.: Zinc metabolism in uremia: Effect of vitamin D on zinc balance and cellular zinc. Kidney Int 37:473, 1990. 12. Mahajan, S., Johnson, P., Abu-Hamdan, D.K., Biersack, K., McDonald, F., and
Prasad, A.: Zinc deficiency in uremia: Effect of vitamin D on cellular zinc, zinc balance and zinc absorption. Clin Res 38:258, 1990. 13. Diebel, L., Kozol, R., Mahajan, S., Abu-Hamdan, D.K., and Thomas, D.: Gastric
ischemia in patients with chronic renal failure. Proc Association of VA Surgeons, 1990. 14. Khoury, S., Abu-Hamdan, D.K., Mahajan, S., Joshi, N. and Veldhuis, J.: Regulation of
the reproductive axis in uremic men. Clin Res 39:265, 1991. 15. Kosgi S, Nimmagadda S, Jena-Mohanty M, Edelstein M, Migdal SD, Abu-Hamdan D.
Macrocytosis in Dialysis Patients Internal Medicine, John D. Dingell VA Medical Center, Detroit, MI; Nephrology, Wayne State University American Society of Nephrology J Am Soc Nephrol 16: 872A, 2005 16. Jamison,R, Et Al, Abu-Hamdan, D listed as one of the participating PIs. Patients with
advanced chronic kidney disease (ACKD) have unexpectedly high rates of death and progression to end stage renal disease (ESRD). J Am Soc Nephrol 17; 202A 2006.
PRESENTATIONS:
National/International

1. Effect of correction of dialysis related hypoxemia on cardiac dysfunction during
hemodialysis (H), Annual Meeting of the Clinical Dialysis and Transplantation Forum, Washington, DC, November l980. 2. Hypoxemia during bicarbonate dialysis, American Society of Nephrology 13th Annual 3. Mechanism of hypoxemia during hemodialysis, American Thoracic Society, Detroit, 4. Zinc metabolism and taste acuity in renal transplant recipients, Third International Congress of Nutrition and Metabolism in Renal Disease, Marseille, France, September 1982. 5. Zinc metabolism in renal transplant patients, 23rd Annual Meeting of American College of Nutrition, Arlington, Virginia, October 1982. 6. Zinc deficiency in patients with nephrotic syndrome, 15th Annual Meeting of American Society of Nephrology, Chicago, Illinois, December 1982. 7. Zinc metabolism and taste acuity following renal transplantation, The American Federation for Clinical Research National Meeting, Washington, DC, April 1983. 8. Zinc metabolism in nephrotic syndrome, International Symposium on Health Effects and Interactions of Essential and Toxic Elements, Lund, Sweden, June 1983. 9. Somata-sensory evoked potentials in uremia, 4th Congress of the International Society for Artificial Organs, Kyoto, Japan, November, 1983. 10. Zinc absorption in uremia, National Meeting of the American Federation for Clinical 11. Zinc absorption in uremia: Effect of phosphate binders, IXth International Congress of Nephrology, Los Angeles, California, June 1984. 12. Zinc absorption in uremia: Effect of phosphate binders and iron supplements, 25th Annual Meeting of the American College of Nutrition, Boston, Massachusetts, September 1984. 13. Copper metabolism in patients with renal disease, The National Meeting of the American Federation for Clinical Research, Washington, DC, May 3-6, 1985. 14. Effect of 1,25 (OH) D on zinc absorption in uremia, 26th Annual American College of Nutrition Meeting, Blacksburg, Virginia, July 22-24, 1985. 15. Copper metabolism in uremia: Effect of dialysis and zinc supplementation, 31st Annual Meeting of the American Society for Artificial Internal Organs, Atlanta, Georgia, May 1-3, 1985. 16. Hypercupremia in uremia: Role of artificial kidneys, Contemporary Management of End Stage Renal Disease, Marrakesh, Morocco, November 10-15, 1985. 17. Hypozincemia in patients undergoing CAPD, 6th National Conference on CAPD, Kansas City, Missouri, February 5-7, 1986. 18. Elevated plasma copper levels in uremia: The role of artificial kidneys, The American Federation for Clinical Research National Meeting, Washington, DC, May 2-5, 1986. 19. Taste Acuity and zinc metabolism in Captopril-treated hypertensive male patients, National Meeting of the American Federation for Clinical Research, San Diego, California, May 1-4, 1987. 20. Taste acuity and zinc metabolism in Captopril-treated hypertensive male patients, American Hypertension Society Meeting, New York, New York, May 17-21, 1987. 21. Factors underlying abnormal zinc metabolism in uremia, 5th International Congress on Nutrition and Metabolism in Renal Disease, Strasboug, France September 1-3, 1988. 22. Gonadal dysfunction in uremia: Luteinizing Hormone Secretion and its responsiveness to gonadotrophin releasing hormone. American Society of Nephrology Meeting, Washington, DC, December 3-6, 1989. 23. Zinc Deficiency in uremia: Effect of vitamin D on cellular zinc, zinc balance and zinc absorption. National meeting of the American Federation for Clinical Nephrology, Washington, DC, May 4-7, 1990. 24. Regulation of the reproductive axis in uremic men. National Meeting of the American Federation for Clinical Research, Seattle Washington, May 2-5, 1991.
Local/Regional

1. Disparate urinary zinc (Zn) handling in response to Zn infusion and amino acids, Michigan Chapter ACP Annual Meeting, Boyne Highlands, Harbor Springs, Michigan, October 1979. 2. Disparate urinary zinc (Zn) handling in response to Zn infusion and amino acids, Department of Medicine Research Forum, Wayne State University, Detroit, Michigan, June 1979. 3. Hypoxemia during hemodialysis, Michigan Chapter American College of Physicians Annual Meeting, Boyne Highlands, Harbor Springs, Michigan, October, 1982. 4. Improvement of renal function after over three years on hemodialysis, Michigan Chapter ACP Annual Meeting, Traverse City, Michigan, October, 1982. 5. Zinc metabolism and taste acuity in renal transplant recipients, Michigan Chapter ACP Annual Meeting, Traverse City, Michigan, October 1982. 6. The role of acetate and blood/membrane interactions in dialysis-related hypoxemia, Regional Meeting of the American College of Physicians, Boyne Highlands, Harbor Springs, Michigan, October 1983. 7. Zinc Metabolism in Nephrotic Syndrome, Regional Meeting of the American College of Physicians, Boyne Highlands, Harbor Springs, Michigan, October 1983. 8. Effect of zinc supplementation and renal transplantation on uremic hyperprolactinemia, Regional Meeting of American College of Physicians, Michigan Chapter, Boyne Highlands, Harbor Springs, Michigan, October 11-14, 1984. 9. Increased renal zinc clearance on Captopril: Report of a case, Regional Meeting of American College of Physicians, Michigan Chapter, Boyne Highlands, Harbor Springs, Michigan, October 11-14, 1984. 10. Effect of phosphate binders and iron supplements on zinc absorption in uremia, Regional Meeting of American College of Physicians, Michigan Chapter, Boyne Highlands, Harbor Springs, Michigan, October 11-14, 1984. 11. Copper metabolism in patients with renal disease: Effect of dialysis, renal transplantation and zinc supplementation, Regional Meeting of the American College of Physicians, Michigan Chapter, Grand Traverse Village, Michigan, September 26-29, 1985. 12. Zinc absorption in uremia: Effect of 1,25 (OH) D, Regional Meeting of the American College of Physicians, Michigan Chapter, Grand Traverse Village, Michigan, September 26-29, 1985. 13. Hypercupremia in dialysis patients, Annual Meeting of the Midwest Section of the American Federation for Clinical Research, Chicago, Illinois, November 6-8, 1985. 14. Zinc balance studies in uremia, Central Society for Clinical Research, Chicago, Illinois, 15. The pattern of LH secretion and responsiveness to pulsatile GnRH in men with uremia. Central Society for Clinical Research. Chicago, Illinois, November 8-10, 1989. 16. Effect of vitamin D on zinc metabolism in uremia. Central Society for Clinical Research, Chicago, Illinois, November 8-10, 1989. 17. High incidence of Macrocytosis in dialysis patients National Kidney Foundation
Invited Presentations:

1. Challenges in treatment of End Stage Renal Disease in AIDS and HIV patients. Meeting of the Michigan Chapter American Nephrology Nurses Association. Frankenmuth, Michigan, April 6, 1993

Source: http://nephrology.med.wayne.edu/cv/abu-hamdan.pdf