Aspirin

MSDS Number: A7686 * * * * * Effective Date: 11/02/01 * * * * * Supercedes:
11/17/99
1. Product Identification
Synonyms: 2-(acetyloxy)benzoic acid; salicylic acid acetate;
acetysalicylic acid
CAS No.: 50-78-2
Molecular Weight: 180.15
Chemical Formula: C9H8O4
Product Codes: 0033
2. Composition/Information on Ingredients
--------------------------------------- ------------ ------------ 3. Hazards Identification
Emergency Overview
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WARNING! HARMFUL IF SWALLOWED OR INHALED.
CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY
TRACT. MAY CAUSE ALLERGIC RESPIRATORY REACTION.
POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH
DEFECTS BASED ON ANIMAL DATA. AFFECTS THE
RESPIRATORY SYSTEM, LIVER, KIDNEYS, EYES, SKIN AND
BLOOD.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your
convenience)
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Health Rating: 1 - Slight
Flammability Rating: 1 - Slight
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT
Storage Color Code: Orange (General Storage)
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Potential Health Effects
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Inhalation:
Causes irritation to the respiratory tract. Exposure may cause an allergy to
develop.
Ingestion:
Extremely large oral doses may cause mild burning pain in the mouth and
stomach, anorexia, nausea, vomiting, intense thirst, diarrhea, dizziness,
irritability, confusion, coma, teratogenic effects, and death from
respiratory failure. The mean lethal dose of aspirin by mouth probably lies
between 20 and 30 grams in adults.
Skin Contact:
May cause irritation.
Eye Contact:
Causes irritation. Contact cause severe pain and may cause eye damage.
Chronic Exposure:
Repeated ingestion may cause tinitus, abnormal bleeding (gastric or
retinal), gastric ulcer, weight loss, mental deterioration, and skin eruptions.
May cause kidney and liver damage in susceptible individuals.
Aggravation of Pre-existing Conditions:
Persons with a history of asthma or allergies to aspirin may be at an increased risk upon exposure to this substance. 4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never
give anything by mouth to an unconscious person. Call a physician.
Skin Contact:
In case of contact, immediately flush skin with plenty of soap and water
for at least 15 minutes. Remove contaminated clothing and shoes. Wash
clothing before reuse. Get medical attention if irritation develops or
persists.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures or by
contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence
of an ignition source is a potential dust explosion hazard. Minimum
explosive dust concentration: 40 g/m3.
Fire Extinguishing Media:
Water spray, foam, or dry chemical.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode.
6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container. 7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from any source of heat or ignition. Isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. 8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
- ACGIH Threshold Limit Value (TLV): 5 mg/m3 (TWA)
Ventilation System:
A system of local and/or general exhaust is recommended to keep
employee exposures below the Airborne Exposure Limits. Local exhaust
ventilation is generally preferred because it can control the emissions of
the contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A
Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible,
a half facepiece particulate respirator (NIOSH type N95 or better filters)
may be worn for up to ten times the exposure limit or the maximum use
concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. A full-face piece particulate respirator
(NIOSH type N100 filters) may be worn up to 50 times the exposure limit,
or the maximum use concentration specified by the appropriate regulatory
agency, or respirator supplier, whichever is lowest. If oil particles (e.g.
lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R
or P filter. For emergencies or instances where the exposure levels are not
known, use a full-facepiece positive-pressure, air-supplied respirator.
WARNING: Air-purifying respirators do not protect workers in oxygen-
deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area. 9. Physical and Chemical Properties
Appearance:
Transparent, colorless crystals.
Odor:
Odorless.
Solubility:
1g/100g water @ 37C.
Specific Gravity:
1.40
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
140C (284F)
Melting Point:
135C (275F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable in dry air.
Hazardous Decomposition Products:
Decomposes to acetic acid and salicylic acids in the presence of moist air.
Carbon dioxide and carbon monoxide may form when heated to
decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers, alkali hydroxides, boiling water, and antipyrine,
aminopyrine, methamine, phenol, phenyl salicylate, and sodium
bicarbonate.
Conditions to Avoid:
Moisture.
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 200 mg/kg; investigated as a mutagen, reproductive
effector.
Reproductive Toxicity:
Reproductive effects recorded on humans.
--------\Cancer Lists\----------------------------------------------- ------------------------------------ ----- ----------- ------ 12. Ecological Information
Environmental Fate:
When released into the soil, this material may leach into groundwater.
When released into the soil, this material may biodegrade to a moderate
extent. When released into water, this material is not expected to
evaporate significantly. This material has an estimated bioconcentration
factor (BCF) of less than 100. This material is not expected to
significantly bioaccumulate. When released into the air, this material may
be moderately degraded by reaction with photochemically produced
hydroxyl radicals. When released into the air, this material may be
removed from the atmosphere to a moderate extent by wet deposition.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements. 14. Transport Information
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\------------------------- ----------------------------------------------- ---- --- ----- -- Acetylsalicylic Acid (50-78-2) Yes Yes Yes --------\Chemical Inventory Status - Part 2\------------------------- ----------------------------------------------- ----- --- ---- - Acetylsalicylic Acid (50-78-2) Yes Yes No --------\Federal, State & International Regulations - Part 1\-------- ----------------------------------------- --- ----- ---- ------ Acetylsalicylic Acid (50-78-2) No No No --------\Federal, State & International Regulations - Part 2\-------- ----------------------------------------- ------ ------ ----- Acetylsalicylic Acid (50-78-2) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: No SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE
STATE OF CALIFORNIA TO CAUSE BIRTH DEFECTS OR OTHER
REPRODUCTIVE HARM.
Australian Hazchem Code: None allocated.
Poison Schedule: S2
WHMIS:
This MSDS has been prepared according to the hazard criteria of the
Controlled Products Regulations (CPR) and the MSDS contains all of the
information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES
IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY
CAUSE ALLERGIC RESPIRATORY REACTION. POSSIBLE BIRTH
DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON
ANIMAL DATA. AFFECTS THE RESPIRATORY SYSTEM, LIVER,
KIDNEYS, EYES, SKIN AND BLOOD.
Label Precautions:
Do not breathe dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical
personnel. Never give anything by mouth to an unconscious person. If
inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact, immediately flush
eyes or skin with plenty of water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. In all cases
call a physician.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 8.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly
trained person using this product. Individuals receiving the
information must exercise their independent judgment in determining
its appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES NO REPRESENTATIONS OR
WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING
WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE WITH RESPECT TO THE INFORMATION SET
FORTH HEREIN OR THE PRODUCT TO WHICH THE
INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT
BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)

Source: http://old.akronschools.com/dotAsset/77442.pdf