D.O. SLOSMAN, R. RIZZOLI, A. DONATH, J.-Ph. BONJOUR. Comparative study of the performances of X-ray and gadolinium 153 bone densitometers at the level of the spine, femoral neck and femoral shaft. Eur J Nucl Med. 17:3- 9,1990.
T. CHEVALLEY, R. RIZZOLI, V. NYDEGGER, D.O. SLOSMAN, L. TKATCH, C.-H. RAPIN, H. VASEY, J.-Ph. BONJOUR. Preferential low bone mineral density of the femoral neck in patients with a recent fracture of the proximal femur. Osteoporos Int. 1:147-154,1991.
J.-Ph. BONJOUR, G. THEINTZ, B. BUCHS, D.O. SLOSMAN, R. RIZZOLI. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73:555-563,1991.
P. AMMANN, R. RIZZOLI, D.O. SLOSMAN, J.-Ph. BONJOUR. Sequential and precise in vivo measurement of bone mineral density in rats using dual-energy X-ray absorptiometry. J Bone Miner Res. 7:311-316,1992.
B. BUCHS, R. RIZZOLI, D.O. SLOSMAN, V. NYDEGGER, J.-Ph. BONJOUR. Bone mineral density of the lumbar spine, the femoral neck and femoral diaphysis in a Genevan population sample. Scweiz Med Wschr. 122:1129-1136, 1992. French.
G. THEINTZ, B. BUCHS, R. RIZZOLI, D.O. SLOSMAN, J.-Ph. BONJOUR. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab. 75:1060-1065,1992.
L. TKATCH, C.-H. RAPIN, R. RIZZOLI, D.O. SLOSMAN, V. NYDEGGER, H. VASEY, J.-Ph. BONJOUR. Benefits of oral protein supplement in elderly patients with fracture of the proximal femur. J Am Coll Nutr. 11:519-525,1992.
C. GABAY, P. RUEDIN, D.O. SLOSMAN, J.-Ph. BONJOUR, M. LESKI, R. RIZZOLI. Bone mineral density in patients with end-stage renal failure. Am J Nephrol. 13:115-123,1993.
P. AMMANN, R. RIZZOLI, J. CAVERZASIO, T. SHIGEMATSU, D.O. SLOSMAN, J.-Ph. BONJOUR. Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density. J Bone Miner Res. 8:1491- 1498,1993.
P. AMMANN, R. RIZZOLI, K. MÜLLER, D. SLOSMAN, J.-Ph. BONJOUR. IGF-1 and pamidronate increase bone mineral density in ovariectomized adult rats. Am J Physiol. 265:E770-776,1993.
G. GEINOZ, C.-H. RAPIN, R. RIZZOLI, R. KRAEMER, B. BUCHS, D.O. SLOSMAN, J.P. MICHEL, J.-Ph. BONJOUR. Relationship between bone mineral density and dietary intakes in elderly. Osteoporos Int. 3:242-248,1993.
J.-Ph. BONJOUR, G. THEINTZ, B. BUCHS, D.O. SLOSMAN, H. CLAVIEN, R. RIZZOLI. Variation in spinal femoral bone mass gain, energy and calcium intake during adolescence. Osteoporos Int. 3 Suppl 1:67-68,1993.
P. RUEDIN, R. RIZZOLI, D.O. SLOSMAN, M. LESKI, J.-Ph. BONJOUR. Effects of oral calcitriol on bone mineral density in patients with end-stage renal failure. Kidney Int. 45:245-252,1994.
D.O. SLOSMAN, R. RIZZOLI, C. PICHARD, A. DONATH, J.-Ph. BONJOUR. Longitudinal measurement of regional and whole body bone mass in young healthy adults. Osteoporos Int. 4:185-190,1994.
J.-Ph. BONJOUR, G. THEINTZ, F. LAW, D.O. SLOSMAN, R. RIZZOLI. Peak bone mass. Osteoporos Int. 4 Suppl 1:7- 13,1994. Review.
T. CHEVALLEY, R. RIZZOLI, V. NYDEGGER, D.O. SLOSMAN, C.-H. RAPIN, J.-P. MICHEL, H. VASEY, J.-Ph. BONJOUR. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D- replete elderly patients. Osteoporos Int. 4:245-252,1994.
P.-E. FOURNIER, R. RIZZOLI, D.O. SLOSMAN, B. BUCHS, J.-Ph. BONJOUR. Relative contribution of vertebral body and posterior arch in female and male lumbar spine peak bone mass. Osteoporos Int. 4:264-272,1994.
R. RIZZOLI, T. CHEVALLEY, D.O. SLOSMAN, J.-Ph. BONJOUR. Sodium monofluorophosphate increases vertebral bone mineral density in patients with corticosteroid-induced osteoporosis. Osteoporos Int. 5:39-46, 1995.
J. PEARSON and the European Quantitation of Osteoporosis Study Group (D.O. SLOSMAN, Geneva). European semi- anthropomorphic spine phantom for the calibration of bone densitometers: assessment of precision, stability and accuracy. Osteoporos Int. 5:174-184, 1995.
S. FERRARI, R. RIZZOLI, T. CHEVALLEY, D.O. SLOSMAN, J.A. EISMAN, J.- Ph. BONJOUR. Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density. Lancet. 345 :423-424,1995.
R. RIZZOLI, M. FORNI, M.A . SCHAAD, D.O. SLOSMAN, A.P. SAPPINO, J. GARCIA, J.-Ph. BONJOUR. Effects of oral clodronate on bone mineral density in patients with relapsing breast cancer. Bone 18 :531-537,1996.
S.L. FERRARI, L.P. NICOD, J. HAMACHER, A. SPILIOPOULOS, D.O. SLOSMAN, T. ROCHAT, J.-Ph. BONJOUR, R. RIZZOLI. Osteoporosis in patients undergoing lung transplantation. Eur Respir J. 9:2378-2382,1996.
P.-E. FOURNIER, R. RIZZOLI, D.O. SLOSMAN, G. THEINTZ, J.-Ph. BONJOUR. Asynchrony between the rates of standing height gain and bone mass accumulation during puberty . Osteoporos Int. 7:525-532,1997.
J.-Ph. BONJOUR, A.-L. CARRIE, S. FERRARI, H. CLAVIEN, D.O. SLOSMAN, G. THEINTZ, R. RIZZOLI. Calcium- enriched foods and bone mass growth in prepubertal girls : a randomized, double-blind, placebo-controlled trial. J Clin Invest. 15:1287-1294,1997.
S. FERRARI, R. RIZZOLI, D.O. SLOSMAN , J.-Ph. BONJOUR. Familial resemblance for bone mineral mass is expressed before puberty. J Clin Endocrinol Metab. 83:358-361,1998.
S. FERRARI, R. RIZZOLI, D.O. SLOSMAN , J.-Ph. BONJOUR. Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms ? J Bone Miner Res. 13:363-370,1998.
M.A . SCHURCH, R. RIZZOLI, D.O. SLOSMAN, L. VADAS, P. VERGNAUD, J.-Ph. BONJOUR. Protein supplements increase serum insulin-like growth factor-1 levels and attenuate proximal femoral bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 15:801-809,1998.
S. FERRARI, R. RIZZOLI, D. MANEN, D.O. SLOSMAN, J-Ph. BONJOUR. Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary, calcium and 3’-end region polymorphisms. J bone Miner Res. 13:925-930,1998.
D.O. SLOSMAN, D.M. PROVVEDINI, P.J. MEUNIER, P.D. DELMAS, M.-C. DE VERNEJOUL, Y. TSOUDEROS, J.Y. REGINSTER. The use of different DXA brands in a multicentre clinical trial: consequences and limits. Journal of Clinical Densitometry. 2:37-44, 1999.
B. TROSSELLO, D.O. SLOSMAN, M. ROTH, B. UEBELHART, C. KIEKENS, A. CHANTRAINE, D. UEBELHART.
Evolution prospective de la composition corporelle et des marqueurs biochimiques du remodelage osseux chez l’hémiplégique. Ann Réadaptation Méd Phys. 42:151-160, 1999.
S.A. ZAMORA, R. RIZZOLI, D.C. BELLI, D.O. SLOSMAN, J.-Ph. BONJOUR. Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girls. J Clin Endocrinol Metab. 84:4541-4544; 1999.
S.P. NIELSEN, D.O. SLOSMAN, O.H. SORENSEN, B. BASSE- CATHALINAT, P. de CASSIN, C. ROUX, P.J. MEUNIER. Influence of Strontium on bone mineral density and bone mineral content measurements by dual X-Ray absorptiometry. Journal of Clinical Densitometry. 2:371-379, 1999.
A. TROMBETTI, M. W. GERBASE, A. SPILIOPOULOS, D.O. SLOSMAN, L.P. NICOD, R. RIZZOLI. Bone mineral density in lung-transplant recipients before and after graft: prevention of lumbar spine post-transplantation-accelerated bone loss by pamidronate. The Journal of Heart and Lung Transplantation. 19:736-743, 2000.
J.-Ph. BONJOUR, T. CHEVALLEY, P. AMMANN, D.O. SLOSMAN, R. RIZZOLI. Gain in bone mineral mass in prepubertal girls 3-5 years after discontinuation of calcium supplementation: a follow-up study. Lancet. 358:1208-1212, 2001.
N. BUCHS, C. HELG, C. COLLAO, B. CHAPUIS, D.O. SLOSMAN, J-.Ph. BONJOUR, R. RIZZOLI. Allogeneic bone marrow transplantation is associated with a preferential femoral neck bone loss. Osteoporos Int. 12:880-886, 2001.
G. GREMION, R. RIZZOLI, D.O. SLOSMAN, G. THEINTZ, J.P. BONJOUR. Oligo-amenorrheic long-distance runners may lose more bone in spine than in femur. Med Sci Sports Exerc. 33:15-21, 2001.
D. HANS, R. RIZZOLI, D. THIEBAUD, K. LIPPUNER, S. ALLAOUA, L. GENTON, F. LUZUY, M.A. KRIEG, P. JAEGER, D.O. SLOSMAN. Reference data in a swiss population: discordance in patient classification using T-scores between the calcaneum, the spine and the femur. J Clin Densitom. 4:291-298, 2001
D. HANS, L. GENTON, M.K. DREZNER, A.M. SCHOTT, R. PACIFICI, L. AVIOLI, D.O. SLOSMAN, P.J. MEUNIER. Monitored impact loading of the hip: initial testing of a home-use device. Calcif Tissue Int. 71:112-120, 2002
D. HANS, W. WACKER, L. GENTON, E. PARIS, C. LE-FLOCH, D.O. SLOSMAN. Longitudinal quality control methodology for the quantitative ultrasound Achilles+ in clinical trial settings. Osteoporos Int. 13:788-795, 2002
D. HANS, S. ALLAOUA, L. GENTON, M. DELMI, H. VUAGNAT, R. RIZZOLI, S. TAHINTZI-ZAWADYNSKI, C. PERRON, C. PICHARD, D.O. SLOSMAN. Is time since hip fracture influencing the discrimination between fractured and non fractured subjects as assessed at the calcaneum by three technologically different quantitative ultrasound devices? Calcif Tissue Int. 71 :485-492, 2002
P.J. MEUNIER, D.O. SLOSMAN, P.D. DELMAS, J.L. SEBERT, M.L. BRANDI, C. ALBANESE, R. LORENC, S. PORS- NIELSEN, M.C. DE VERNEJOUL, A. ROCES, J.Y. REGINSTER. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis – a 2-year randomized placebo controlled trial. J Clin Endrocrinol Metab. 87:2060-2066, 2002
Hans D, Alekxandrova I, Njeh C, Le-Floch C, Conicella G, Laugier P, SLOSMAN DO. Appropriateness of internal digital phantoms for monitoring the stability of the UBIS 5000 quantitative ultrasound device in clinical trials. Osteoporos Int. 2005 Apr;16(4):435-45.
O. BRUYERE, C ROUX, J BADUNSKI, G ISAIA, MC de VERNEJOUL, J CANNATA, S ORTOLANI, D.O. SLOSMAN, J DETILLEUX, JY REGINSTER. Relationship between change in femoral neck bone mineral density and hip fracture incidence during treatment with strontium ranelate. Curr Med Res Opin 2007 23:3041-3045.
BRUYERE, C ROUX, J DETILLEUX, D.O. SLOSMAN, TD SPECTOR, P FARDELLONE, K BRIXEN, JP DEVOGEALER, M DIAZ-CURIEL, C ALBANESE, JM KAUFMAN, S PORS-NIELSEN, JY REGINSTER. Relationship between bone minéral density changes and fracture risk reduction in patients treated with strontium ranelate. JClin Endocrinol Metab 2007 92:3076-3081.
C. KENDLER D.L., ADACHI J.D., JOSSE R.G., D.O. SLOSMAN. Monitoring strontium ranelate therapy in patients with osteoporosis. Osteoporosis Int 2009. 7:1101-1106.
C. PICHARD, D. SLOSMAN, J-C. CHEVROLET, Ph. JOLLIET, U. KYLE. Interactions de la sous-nutrition et de la renutrition sur le tissu musculaire. Nutr Clin Metab 6 : 209-218, 1992.
T. ROCHAT, D.O. SLOSMAN, C. PICHARD, D.C. BELLI. Body composition analysis by dual energy X-ray absorptiometry in adults with cystic fibrosis. Chest 106 :800-805,1994.
C. PICHARD, U. KYLE, D.O. SLOSMAN, P. PENALOSA. Does fat-free mass as measured by bioelectrical impedance permit estimation of energy expenditure in hospitalized anorexia nervosa patients ? Clin Nutr 15 :109-114, 1996.
C. PICHARD, Ph. JOLLIET, J.C. CHEVROLET, J.A. ROMAND, D.O. SLOSMAN. Recombinant human growth hormone in chronic and acute respiratory insufficiency. Horm Res. 45:222-229,1996.
F. CURTIN, A. MORABIA, C. PICHARD, D.O. SLOSMAN. Body mass index compared to dual-energy X-ray absorptiometry: evidence for a spectrum bias. J Clin Epidemiol. 50:837-843,1997.
C. PICHARD, U. KYLE, J.-P. JANSSENS, L. BURDET, T. ROCHAT, D.O. SLOSMAN, J.-W. FITTING, D. THIEBAUD, M. ROULET, J.-M. TSCHOPP, M.- LANDRY, Y. SCHUTZ. Body composition by X-ray absorptiometry and bioelectrical impedance in chronic respiratory insufficiency patients. Nutrition. 13:952-958,1997.
C. PICHARD, U.G: KYLE, G GREMION, G GERBASE, D.O. SLOSMAN. Body composition by X-ray absorptiometry and bioelectrical impedance in female runners. Med Sci Sports Exerc. 29:1527-1534,1997.
C. PICHARD, P. SUDRE, V. KARSEGARD, S YERLY, D.O. SLOSMAN, V. DELLEY, L PERRIN, B HIRSCHEL. A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study. AIDS. 1:53-63,1998.
U.G. KYLE, C. PICHARD, D.O. SLOSMAN. Normal values for fat-free and fat mass in 1678 healthy adults measured by bioelectrical impedance analysis (BIA). Clinical Nutrition. 17 Suppl. 1:49,1998.
U.G. KYLE, C. PICHARD, T. ROCHAT, D.O. SLOSMAN, J.-W. FITTING, D. THIEBAUD. New bioelectrical impedance formula for patients with respiratory insufficiency : comparison to dual-energy X-ray absorptiometry. Eur Respir J. 12:960- 966, 1998.
A. MORABIA, A. ROSS, F. CURTIN, C. PICHARD, D.O. SLOSMAN. Relation of body mass index (BMI) to dual-energy X- ray absorptiometry measure of fatness. Br J Nutrition. 82:49-55, 1999.
C. PICHARD, U.G. KYLE, D.O. SLOSMAN. Fat-free mass in chronic illness: comparison of bioelectrical impedance and dual-energy X-Ray absorptiometry in 480 chronically ill and healthy subjects. Nutrition. 15:668-676, 1999.
104- C. PICHARD, U.G. KYLE, P.J. JOLLIET, D.O. SLOSMAN, T. ROCHAT, L. NICOD, J. ROMAND, N. MENSI, J.C. CHEVROLET. Treatment of cachexia with recombinant growth hormone in a pre-lung transplantation patient: a case report. Crit Care Med. 27:1639-1642, 1999.
C. PICHARD, U. G. KYLE, D. BRACCO, D. O. SLOSMAN, A. MORABIA, Y. SCHUTZ. Reference values of fat-free and fat masses by bioelectrical impedance analysis in 3393 healthy subjects. Nutrition. 16:245-254, 2000.
U.G. KYLE, L. GENTON, L. KARSEGARD, D.O. SLOSMAN, C. PICHARD. Single prediction equation for bioelectrical impedance analysis in adults ages 20-94 years. Nutrition 17:248-253, 2001.
U.G. KYLE, L. GENTON, D.O. SLOSMAN, C. PICHARD. Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years. Nutrition 17:534-541, 2001
U.G. KYLE, L. GENTON, D.O. SLOSMAN, C. PICHARD. Fat-free and fat mass percentiles in 5225 healthy subjects aged 15 to 98 years. Nutrition 17:534-541, 2001
U.G. KYLE, L. GENTON, D. HANS, L. KARSEGARD, D.O. SLOSMAN, C. PICHARD. Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. Eur J Clin Nutrition. 55:663-672, 2001
U.G. KYLE, A. MORABIA, D.O. SLOSMAN, N. MENSI, P.-F. UNGER, C. PICHARD. Contribution of body composition to nutritional assessment at hospital admission in 995 patients: a controlled population study. Br J Nutrition. 86:725-731, 2001
U.G. KYLE, L. GENTON, D. HANS, V.L. KARSEGARD, J.-P. MICHEL, D.O. SLOSMAN, C. PICHARD. Total body mass, fat mass, fat-free mass, and skeletal muscle in older people: cross-selectional differences in 60 year-old-persons. J Am Geriatr Soc. 49:1633-1640, 2001
U.G. KYLE, L. NICOD, J.A. ROMAND, D.O. SLOSMAN, A. SPILIOPOULOS, C. PICHARD. Four-year follow-up of body composition in lung transplant patients. Transplantation. 75:821-828, 2003
U.G. KYLE, L. GENTON, G. MENTHA, L. NICOD, D.O. SLOSMAN, C. PICHARD. Reliable bioelectrical impedance analysis estimate of fat-free mass in liver, lung, and heart transplant patient. Journal of Parenteral Nutrition. 2001 Mar- Apr;25(2):45-51.
L. GENTON, D. HANS, U.G. KYLE, V.L. KARSEGARD, D.O. SLOSMAN, C. PICHARD. Half-body dual energy X-ray absorptiometry (DXA) predicts whole body composition (WBC) in obese patients. Clin Nutr. 2003 Aug;22(S1):S22-3.
U.G. KYLE, C. HELG, R. RIZZOLI, D. HANS, D.O. SLOSMAN, C. PICHARD. Longitudinal follow-up of body composition after bone marrow transplant (BMT). Clin Nutr. 2003 Aug;22(S1):S2-3.
U.G. KYLE, G. GREMION, L. GENTON. D.O. SLOSMAN, A. GOLAY, C. PICHARD. Physical activity and fat-free and fat mass as measured ba bioelectrical impedance in 3853 adults. Med Sci Sports Exerc. Clin Nutr. 2004 Feb;23(1):79-88.
U.G. KYLE, G. L. GENTON. GREMION, D.O. SLOSMAN, C. PICHARD. Aging, physical activity and height-normalized body composition parameters. Clin Nutr. 2004 Feb;23(1):79-88.
U.G. KYLE, G. L. GENTON, H.C. LUKASKI, Y.M. DUPERTUIS, D.O. SLOSMAN, D. HANS, C. PICHARD. Comparison of fat-free mass and body fat in Swiss and American adults. Nutrition. 2005 Feb;21(2):161-9.
To ensure delivery of our emails, add your address book. Please note this is for outgoing mail only. If you Osteoporosis in women — and More information men? Most people think of osteoporosis — a condition characterized by a loss of Get your copy of bone mass and density — as mainly a health problem for older women. If you’re male, you may have breathed a small sigh of relief —
DEPARTMENT OF HEALTH & HUMAN SERVICES Food and Drug Administration Rockville, MD 20857ANDA 091624 Kremers Urban Pharmaceuticals Inc. U.S. Agent for: Kudco Ireland Limited Attention: Kurt Zimmer RA Manager 1101 C Avenue West Seymour, IN 47274 Dear Sir: This is in reference to your abbreviated new drug application (ANDA) dated July 15, 2009, submitted pursuant to section 505(j) of the Fe