Gate question papers pharmaceutical sciences 2003

GATE question papers Pharmaceutical Sciences (PY) 2003 GATE question papers Pharmaceutical Sciences (PY) 2003
Q.1  30 Carry One Mark Each.
Colchicine is biogenetically derived from one of the following The diagnostic character for the microscopical identification of Kurchi bark is slereids containing calcium oxalate crystals It is possible to initiate the development of complete plants from callus cell cultures by suitable The starting material for the synthesis of ALPRAZOLAM is Simplification of Morphinan system gave one BENZOMORPHAN derivative (S)-2-(6-ethoxy-2-napththyl)-acetic acid (B) (S)-2-(6-methoxy-2-napththyl)-acetic (C) (S)-2-(6-ethoxy-2-napththyl)-propionic (D) (S)-2-(6-methoxy-2-napththyl)-propionic The metabolic function of Riboflavin involves the following X-ray spectral lines Ka doublet arises from transition of electrons from a The method of expressing magnetic field strength is Page 1 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 A widely accepted detector electrode for pH measurement is Commercial production of citric acid is carried out by the microbial culture of For thermophilic microorganisms, the minimum growth temperature required is can tolerate oxygen and grow better in its presence do not tolerate oxygen and die in its presence can grow in presence of atmospheric oxygen macromolecule involved in the protein synthesis a hybrid DNA that is formed by joining pieces DNA endogenous substance secreted by one type of cell Lactose intolerance is because of the lack of galactose-1-phosphate-uridyl transferase Synthesis of UREA takes place exclusively in A term which describes a cofactor that is finally bound to an apoenzyme is How many parts of 10% ointment be mixed with 2 parts of 15% ointment to get 12% ointment? The correct non-ionic surfactant used as a penetration enhancer in the preparation of mucoadhesives One of the ex-officio member of the Pharmacy Council of India is Director General of Indian Veterinary Research Institute Page 2 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 The Schedule in Drugs and Cosmetics Act that deals with the requirements and guidelines for clinical trials, import and manufacture of new drugs is A retardant material that forms a hydrophilic matrix in the formulation of matrix tablets is A drug which causes pink to brownish skin pigmentation within a few weeks of the initiation of therapy is The risk of Digitalis toxicity is significantly increased by concomitant administration of An agent used in Prinzmetal angina has spasmolytic action which increases coronary blood supply is An organism which has been implicated as a possible cause of chronic gastritie and peptic ulcer is A 5HTID receptor agonist useful in migraine is Q.31  80 Carry Two Marks Each.
At present, different species of Papaver such as P. bracteatum and P. orientale are being cultivated instead of P.somniferum because they contain a hypolipidemic agent obtained from cotton plants containing multifunctional compound (±) a lipid obtained from Arctium lappa, asteraceae and traditionally used for the treatment of cathartic glucoresin obtained from Ipomoea orizabensis and used since ancient time a hypolipidemic agent obtained from Commiphora mukul consisting of a mixture of sterols including Z-pregna-(20)-diene-3, 16-dione In nitrofurantoin synthesis, 5-nitrofurfuraldehyde diacetate is treated with one of the following intermediate in presence of CH3COOH+H2SO4 + C2H5 OH Page 3 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 4-hydroxy-3-hydroxymethyl benzaldehyde is treated with acetic anhydride and then kept with ether solvent, t-butyl cyanide and acetic acid for ten days. Resulting compound is reduced with LiAlH4 in 2-iminothiazolidine is treated with phenyloxirane to get a drug used in roundworm infection is Thiamine hydrochloride on treatment with alkaline potassium ferricyanide gives neopyrithiamine with orange yellow colour A new drug delivery system which is composed of phospholipids that spontaneously form a multilamellar concentric bilayer vesicles with layers of aqueous media separating the lipid layers is Unless otherwise stated in the individual monograph of the pharmacopoeia, in the disintegration test for enteric coated tablets, first the dissolution is carried out in What is the proportion of NaCl required to render a 1.5% solution of drug isotonic with blood plasma? The freezing point of 1% w/v solution of drug is -0.122°C and that of NaCl is -0.576°C IR Spectra appear as dips in the curve rather than maxima as in UV-Visible spectra because it is a plot of ESR is applied to only those substances showing paramagnetism which is due to the magnetic Rotation of electrons about the proton generates a secondary magnetic field which may oppose the applied magnetic filed. The portion is then said to be The analyte is used in the form of a solution in flame photometry because it should undergo Page 4 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 The mechanism of antiparasitic action of Mebendazole and thiabendazole involves stimulation of acetylcholine receptors at neuromuscular junctions interference with microtubule synthesis and assembly Isoniazid is a primary antitubercular agent that causes ocular complications that are reversible if the drug is discontinued should never be used due to hepatotoxic potential Decreased risk of Atherosclerosis is associated with increase in The mechanism of action of Paclitaxel is bind to DNA through intercalation between specific bases and block the synthesis of new RNA or DNA, cause DNA strand scission mitotic spindle poison through the enhancement of tubulin polymerization competitive partial agonist œ inhibitor of estrogen and binds to estrogen receptors S-Phase specific antimetabolite that is converted by deoxykinase to the 5-mononuleotid Lycopodium spore method can be used to find out percentage purity of crude drugs which contain well defined particles which can be counted characteristic particles of irregular thickness, the length of which can be measured The microscopical character of flower buds of Eugenia caryophyllus is collenchymatous parenchyma containing in its outer part numerous ellipsoidal small translucent endosperm containing aleurone grains wide parenchymatous starchy cortex, the endosperm containing volatile oil outer surface consisting of external perisperm, rough, dark brown with reticulate furrows In protein biosynthesis, each amino acid recognizes its own codon by a direct interaction with the m-RNA template is added in its proper place to a growing peptide chain through the "adaptor" function of t- is first attached to an anticodon specific for the amino acid undergoes fidelity translation which is assured by the presence of traces of DNA on the a freeze dried preparation containing antitoxic globulin a preparation containing specific globulin or its derivatives obtained by purification of hyperimmune serum or plasma of healthy horses a sterile preparation containing antitoxic globulin a sterile preparation containing antitoxic globulins obtained by purification of hyperimmune Page 5 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003
Q.52-58 are multiple selection items. P, Q, R, S are the options. Two of these options are correct.
Choose the correct combination among A, B, C and D.
Total ash value in case of crude drug signifies (R) addition of extraneous matter such as sand, stone etc. The compounds listed below contain ,  ad  electrons A 60 year old patient presents with glaucoma. Therapy should include Measurement of particle size in pharmaceutical Aerosols is by The common attributes of ascorbic acid, an antiscrobutic vitamin, are (P) exist in nature in both reduced and oxidized form and in a state of reversible equilibrium (Q) has a keto-enol system in the molecule (R) has an aldehyde group since it gives positive Schiff‘s reaction (S) salt forming properties are due to the presence of free carboxyl group Two properties of Radiopharmaceuticals are (Q) very long half-life to provide enough exposure to get imaging information (R) short half-life to minimize radiation exposure yet long enough to get imaging information (S) rapid localization in target tissue and quick clearance from non-target organs Two correct statements concerning vitamin D are (P) the active molecule 1, 25-dihydroxy cholecalciferol binds to intracellular receptor proteins (Q) cholecalciferol is found in vegetables (R) 1, 25-dihydroxy-D3 is the most potent vitamin D metabolite (S) it is required in the diet of individuals exposed to sunlight Page 6 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003
Q.59-65 ARE —MATCHING“ exercises. Match Group I with Group II. Choose the correct
combination among the alternatives A, B, C and D.
Page 7 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 4, 4‘ Dimethoxy benzophenone is treated with 4- estradiol methoxy benzoyl chloride + Mg, resulting product is Deoxyanisoin is alkylated and product subjected to Grignard reaction, the resulting tertiary alcohol is dehydrated and demethylated with alcoholic KOH By Pinacol reduction of p-hydroxy propiophenone From Estrone by the action of Potassium acetylide which on further conversion inhibits purine Interferes with the cell cycle of activated
Data for Q.66 œ 90 are based on the statement/problem . Choose the correct answer for each
question from among the options A, B, C and D.

Data for questions 66 to 68:
Leaves of Digitalis purpurea were subjected to morphological, microscopical and chemical screening.
Morphological character with respect to the leaf is multicellular, uniseriate with 2-7 cells multicellular, uniseriate with 10-14 cells multicellular, multiseriate with 10-14 cells Page 8 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 Page 9 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003
Data for questions 69 and 70:
In a synthetic procedure 5-chloro-2, 4-diamino sulfomyl aniline is treated with P to obtain 7-amino sulfomyl-6-chloro-3-chloro-methyl-2H-1, 2, 4-benzothiadiazin-1:1 dioxide. Subsequently it is refluxed with C6H5-CH2-SH 3-benzyl methyl-6-chloro-2H-1, 2, 4-benzothiadiazine-7 sulphonamide 1, 1-dioxide 3-benzyl thiomethyl-6-chloro-2H-1, 2, 4-benzothiadiazine-7 sulphonamide 1, 1-dioxide 3-benzyl thiomethyl-5-chloro-2H-1, 2, 3-benzothiazine-7 sulphonamide 1, 1-dioxide 3-benzyl thiomethyl-5-chloro-2H-1, 2, 3-benzothiadiazine-7 sulphonamide 1, 1-dioxide
Data for questions 70 to 73:
Proguanil is synthesized by diazotization of p-chloroaniline and treating with dicynamide to yield p- chlorophenyldicyandiamide which is converted to Proguanil by reaction with an aliphatic amine. Proguanil is metabolized to a triazine derivative which is an active metabolite. What is the reagent used for diazotization?
Data for questions 74 to 76:
Calculate the max for the following compounds. Base value for Benzaldehyde in ethanol is 250 mm.
74.
max of p-hydroxy benzaldehyde in nm is max of o-chlorobenzaldehyde in nm is
Data for questions 77 and 78:
In the assay of Folic acid I.P., a weighed quantity is dissolved in 0.1 M NaOH solution and subsequently treated with Zn and HCl. The resulting product is mixed with ammonium sulphamate, kept for 2 minutes and a reagent is added to get final coloured product whose absorbance is measured Select the product obtained when folic acid is heated with Zn + HCl Page 10 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 Page 11 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 Select the reagent used for the development of colour N-1-naphthyl ethylene diamine didydrochloride Data for questions 79 and 80:
Parkinsonism is a common neurological movement disorder. Signs include rigidity of skeletal muscles, akinesia, flat facies and tremors at rest. Both L-DOPA and Carbidopa are used. it inhibits aromatic L-aminoacid decarboxylase Select the specific unwanted effect of L-DOPA
Data for questions 81 and 82:
The decomposition of a drug in aqueous acid solution was found to follow first order reaction. The initial concentration was found to be 0.056 M. The concentration after a period of 12 hours was 4.10 × 102 moles/litre. The reaction rate constant is 0.02599  hr1. 81. What is the quantity of drug remaining undecomposed after 8 hours? What is the amount of drug deteriorated during the period of 24 hours?
Data for questions 83 to 85:
In a formulation development laboratory, you have to formulate an oral dosage from containing olive oil, vitamin A and water. Suggest a substance to be incorporated into the formulation Select one of the appropriate labeling directions Page 12 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003 Page 13 of 14
GATE question papers Pharmaceutical Sciences (PY) 2003
Data for questions 86 and 87:
Successive solvent extraction of a crude drug with petroleum ether, benzene, chloroform, ethyl alcohol and water was performed. Qualitative chemical testing of petroleum ether extract gave positive Keller-Kiliani and Salkowski's reactions. Ethyl alcohol and aqueous extract gave positive FeCl3 reaction and acqueous extract What constituents are present in the petroleum ether/benzene extract? What constituents are present in the ethyl alcohol and aqueous extracts?
Data for questions 88 to 90:
A business executive while playing tennis complained of chest pain and ws brought to emergency room. He has history of mild hypertension and elevated blood cholesterol. ECG changes confirmed the diagnosis of myocardial infraction. The decision is made to open his occluded artery by using thrombolytic agent and also Mechanism of action of antithrombic lagent is conversion of plasminogen to plasmin (B) Page 14 of 14

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