R3057

Material Safety Data Sheet
Personal Protective Equipment
Health Hazard
Fire Hazard
Reactivity
Section 1. Chemical Product and Company Identification
Page Number: 1
Common Name/
all-trans-Retinoic acid
Trade Name
Number(s).
Manufacturer
SPECTRUM LABORATORY PRODUCTS INC.
14422 S. SAN PEDRO STREET Commercial Name(s)
Aberel; Airol; Aknoten; Dermairol; Effederm; Epi-aberel; Eudyna; Retin-A; Retinoic acid; Tretin M; Tretinoin; Vitamin A acid; VitaminA acid, all trans- 2 , 4 , 6 , 8 - N o n a t e t r a e n o i c a c i d ,3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-; IN CASE OF EMERGENCY
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cycloyhexen-1-yl)2,4,6,8-nonatetraenoic CHEMTREC (24hr) 800-424-9300
a c i d ; a l l - E - R e t i n o i c a c i d ; a l l - t r a n s - b e t a - R e t i n o i c a c i d ;beta-all-trans-Retinoic acid; beta-RA; beta-Retinoic acid;trans-Retinoic acid Chemical Name
Chemical Family
Chemical Formula
Supplier
SPECTRUM LABORATORY PRODUCTS INC.
14422 S. SAN PEDRO STREETGARDENA, CA 90248 Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3)
STEL (mg/m3)
CEIL (mg/m3)
% by Weight
Toxicological Data
all-trans-Retinoic acid:
on Ingredients
Acute: 1100 mg/kg [Mouse]. 2000 mg/kg [Rat].
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all-trans-Retinoic acid
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Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant). Slightly hazardous in case of ingestion, of
Potential Chronic Health
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Section 4. First Aid Measures
Eye Contact
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for atleast 15 minutes. Get medical attention.
Skin Contact
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Removecontaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Getmedical attention.
Serious Skin Contact
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediatemedical attention.
Inhalation
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Getmedical attention.
Serious Inhalation
Ingestion
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tightclothing such as a collar, tie, belt or waistband.
Serious Ingestion
Section 5. Fire and Explosion Data
Flammability of the Product
May be combustible at high temperature.
Auto-Ignition Temperature
Flash Points
Flammable Limits
Products of Combustion
These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of
Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
and Instructions
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on
As with most organic solids, fire is possible at elevated temperatures Material in powder form, capable of creating Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Hazards
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Section 6. Accidental Release Measures
Small Spill
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning byspreading water on the contaminated surface and dispose of according to local and regional authorityrequirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading wateron the contaminated surface and allow to evacuate through the sanitary system.
Section 7. Handling and Storage
Precautions
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do notingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately andshow the container or the label. Avoid contact with skin and eyes.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).
Refrigerate. Sensitive to light. Store in light-resistant containers.
Section 8. Exposure Controls/Personal Protection
Engineering Controls
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels belowrecommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure toairborne contaminants below the exposure limit.
Personal Protection
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill
to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialistBEFORE handling this product.
Exposure Limits
Section 9. Physical and Chemical Properties
Physical state and appearance
Molecular Weight
pH (1% soln/water)
Boiling Point
Melting Point
Critical Temperature
Specific Gravity
Vapor Pressure
Vapor Density
Volatility
Odor Threshold
Water/Oil Dist. Coeff.
Ionicity (in Water)
Dispersion Properties
See solubility in water, diethyl ether.
Solubility
Soluble in diethyl ether.
Insoluble in cold water, hot water.
Slightly soluble in alcohol, chloroform.
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Section 10. Stability and Reactivity Data
Stability
Instability Temperature
Conditions of Instability
Excess heat, incompatible materials, dust generation.
Incompatibility with various
substances
Corrosivity
Special Remarks on
Reactivity
Special Remarks on
Corrosivity
Polymerization
Section 11. Toxicological Information
Routes of Entry
Toxicity to Animals
Acute oral toxicity (LD50): 1100 mg/kg [Mouse].
Chronic Effects on Humans
Other Toxic Effects on
Hazardous in case of skin contact (irritant).
Slightly hazardous in case of ingestion, of inhalation.
Special Remarks on
Toxicity to Animals
Special Remarks on
May affect genetic material (mutagenic).
Chronic Effects on Humans
May cause adverse reproductive effects and birth defects (teratogenic).
May cause cancer based on animal test data.
Special Remarks on other
Toxic Effects on Humans
Skin: Causes skin irritation.
Eyes: Causes eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: May be harmful is swallowed. May cause gastrointestinal tract irritation with nausea, vomiting,diarrhea, anorexia. May affect respiration (respiratory depression)Chronic Potential Health Effects:Skin: Prolonged or repeated skin contact may cause dermatitis.
Ingestion: Prolonged or repeated ingestion ,may cause weight loss. It may also affect the blood (pigmented ornucleated red blood cells, change in red blood cell count, normocytic anemia), bone marrow, liver, spleen, thymus,spinal cord, behavior/central nervous system(somnolence, ataxia, hallucinations), musculoskeletal system.
Section 12. Ecological Information
Ecotoxicity
BOD5 and COD
Products of Biodegradation
Possibly hazardous short term degradation products are not likely. However, long term degradation products mayarise.
Toxicity of the Products
The products of degradation are less toxic than the product itself.
of Biodegradation
Special Remarks on the
Products of Biodegradation
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Section 13. Disposal Considerations
Waste Disposal
Waste must be disposed of in accordance with federal, state and local environmentalcontrol regulations.
Section 14. Transport Information
DOT Classification
Not a DOT controlled material (United States).
Identification
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
Federal and State
California prop. 65: This product contains the following ingredients for which the State of California has found to Regulations
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:all-trans-Retinoic acidCalifornia prop. 65: This product contains the following ingredients for which the State of California has found tocause birth defects which would require a warning under the statute: all-trans-Retinoic acidTSCA 8(b) inventory: all-trans-Retinoic acid California
California prop. 65: This product contains the following ingredients for which the State of California has found Proposition 65
to cause cancer which would require a warning under the statute: No products were found.
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has foundto cause birth defects which would require a warning under the statute: all-trans-Retinoic acid Other Regulations
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
206-129-0).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
Other Classifications
WHMIS (Canada)
It has not yet been validated by the Service du repertoire toxicologique. However, it mightbe classified as WHMIS Class D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC)
R36/38- Irritating to eyes and skin.
immediately with plenty of water and seekmedical advice.
S37- Wear suitable gloves.
S46- If swallowed, seek medical adviceimmediately and show this container or label.
HMIS (U.S.A.)
Health Hazard
National Fire Protection
Flammability
Fire Hazard
Association (U.S.A.)
Reactivity
Reactivity
Personal Protection
Specific hazard
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WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Dust respirator. Be sure to use anapproved/certified respirator orequivalent.
Section 16. Other Information
MSDS Code
References
Other Special
Considerations
Validated by Sonia Owen on 8/6/2007.
Verified by Sonia Owen.
Printed 9/25/2007.
CALL (310) 516-8000
Notice to Reader
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All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,
Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.

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