Microsoft word - small animal parasiticides 05.doc

PARASITICIDES USED IN SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
(Ivermectin)
Pre-cleaning of ears not required Water-based formula For adult ear mites; Effectiveness against eggs and immature stages has not been proven (Epsiprantel)
Logarithmic dosage; (*increase dosge for Mesocestoides, (Praziquantel)
Spirometra, Diphyllobothrium, flukes like Paragonimus, Platynosum, Heterobilharzia.) Use only in dogs > 4 weeks, (Praziquantel/
Pyrantel pamoate)
(Praziquantel/Pyrantel
pamoate/Febantel)
(Ivermectin/Pyrantel pamoate)
(Ivermectin)
Also effective against heartworm L3’s/L4’s; (Milbemycin Oxime)
Microfilaricidal; safe in collies. For dogs > 4 weeks old. Extra label 0.5 mg-1mg/kg PO once/wk/3 wks *Pneumonyssoides caninum (mite); daily for 90 days plus? *Demodex; 2 mg/kg PO once/wk/3 wks Sarcoptes (Milbemycin oxime)
PARASITICIDES USED IN SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
Not recommended
(Ivermectin)
This dosage is safe for Collies; may require 4 weeks
to kill all MF; sterilizes male worms. NOT
RECOMMENDED!

Dogs – EXTRA-LABEL 200-400 ug/kg PO,SC
*Capillaria spp, *Trichuris vulpis, *T. canis, (not
Toxascaris leonine), *Ancylostoma caninum, *A.
braziliense, *Uncinaria stenocephala,
*Angiostrongylus, *Physaloptera, *Dipetalonema,
*Sacroptes, *Pneumonyssoides, *Otodectes
Dogs – EXTRA-LABEL 300 ug/kg SC on
gestation d 0,30,60, & post-whelp d 10 = reduced
prenatal infection *T canis
Dogs – EXTRA-LABEL 300-600 ug/kg PO daily/2
mo *Demodex
Cats – EXTRA-LABEL 200-400 ug/kg PO, SC
*Sarcoptes, *Notoedres, *Otodectes, *Cheyletiella
(may need repeated doses)
1% aural solution For cats > 4 weeks old (Milbemycin oxime)
Very safe; ideal for pups; +cats dose is 4X dog dose; (Pyrantel pamoate)
stir before use. Also kills *Physaloptera. Very safe drug; 3 d for R,H,W, Taenia and (Fenbendazole)
*Giardia; (*10-14 days for Angiostrongylus, Capilaria ssp, Filaroides/Oslerus, Paragonimus, Heterobilharzia and 28 day for Mesocestoides). +cats 50 mg/kg for 5 d H,R, Taenia, Giardia; 10-14 d for Aelurostrongylus, Capillaria spp, Paragonimus, other flukes. PARASITICIDES USED IN SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
Not for use with other anthelmintics, muscle (Dichlorvos)
relaxants, cholinestrerase inhibitors, tranquilizers, antifilarial drugs, animals with constipation, impaired liver function, circulatory failure, heart-worm infections, or infectious disease For dogs greater than 10 days old (Selamectin)
Also extra label for * Chewing/Sucking Lice Administered to dam @ 40, 10 d pre-whelping & 40, 10 d post-whelping reduced transplacental & lactogenic transmission of T. canis (Milbemycin oxime/Lufenuron)
Extra-label for dogs and cats; variable efficacy; (Albendazole)
teratogenic, myelosuppression, abortion, etc. *Paragonimus *Trichinella *Giardia, *Leishmania COMPOUNDS EFFECTIVE AGAINST VARIOUS STAGES OF Difilaria immitis
APPROVED
SPECTRUM
SUPPLIED
Ivermectin
Not recommended
This dosage is safe for Collies; may require 4 weeks to kill all MF; sterilizes male worms microfilaricidal, but causes occult infections after 5- 8 months; 14-24 monthly doses killed 4 mo. old larvae For dogs > 6 weeks old Ivermectin/ Pyrantel pamoate
Same remarks as for Heartgard-30 for dogs > 6 Melarsomine dihydrochloride
2 doses I.M. 24 hrs. apart; less toxic than caparsolate; single regimen 90% effective; 2nd regimen after 4 mos. Raises efficacy to 98% Milbemycin oxime
Microfilaricidal; causes occult infections; maybe shock from dying mf; safe in Collies For dogs > 4 weeks old 5.75, 11.5, 23 mg Virtually no contraindications chewable tablets Milbemycin oxime Plus
Lufenuron
Withdrawn from Market
Moxidectin(ProHeart/Proheart 6)
microfilaricidal For dogs > 8 weeks old HW efficacy for 6 months; purportedly not microfilaricidal /For dogs > 6 months old Selamectin
Efficacy for HW prevention – 60 days; unaffected by bathing or swimming ;For dogs > 6 wks, cats > 8 wks / Extra label * Chewing/Sucking Lice/when administered to dam @ 40, 10 d pre- whelping & 40, 10 d post-whelping reduced transplacental & lactogenic transmission to T. canis ANTIPROTOZOAL COMPOUNDS FOR SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
125, 250, 500 mg Used for enteritis associated with coccidiosis in (Sulfadimethoxine)
**Allopurinol
Used as a uric acid reducer in dogs, cats, birds; use with caution in animals with renal or hepatic An antimicrobial; No label claim for protozoa wks or 12.5-25 mg/kg IM every 12 hrs for 2 wks (may also stop oocysts shedding) Dogs: 10-20 mg/kg every 12 hrs for 2 wks (diminazene aceturate)
Extra-label for dogs and cats; Possible thiamine deficiency; used prophylactically (treatment usually 1.25 gm mixed with ration for 4 puppies for up to 7 days Cats/dogs: 300-400 mg/kg PO for 5 days or 110-220 mg/kg for 7-12 days ANTIPROTOZOAL COMPOUNDS FOR SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
Extra-label for dogs and cats; Vomition, diarrhea, ataxia; not for pregnant or lactating bitches; Do not use simultaneously with exposure to (Imidocarb dipropionate)
cholinesterage-inhibitors, pesticides, chemicals Meglumine antimonite
Use for Giardia is extra-label; relapses are common (Fenbendazole)
(Sulfadimethoxine/Ormetoprim
ANTIPROTOZOAL COMPOUNDS FOR SMALL ANIMALS
APPROVED
SPECTRUM
SUPPLIED
No label claims for coccidiosis or toxoplasmosis Bone marrow suppression may occur; add folinic acit (5 mg/day) or yeast (100 mg/kg) to diet No label claims for coccidiosis or toxoplasmosis; (Sulfadiazine/Trimethoprim)
Extra-label for dogs and cats; variable efficacy; (Albendazole)
teratogenic, myelosuppression, abortion, etc.
** = not approved for use in small animals.
+ = not approved for use in cats
*Parasites not included on label
H = hooks; R = ascarids; W = whips; C = canine; F = feline; Bv = bovine; Eq = equine

Source: http://www.vet.utk.edu/diagnostic/parasitology/Small%20Animal%20Parasiticides%2005.pdf