Abstract title centered and bold in upper- and lowercase
Preparation and in vitro evaluation of tretinoin nano-emulsion system
Mahsa Sabouri 1, Effat Sadat Farboud 2, Mansour Nasiri Kashani 3
Zahra Jafari Azar 1, Saman Ahmad Nasrollahi 3٭
1. Department of Pharmaceutics, Islamic Azad University of Pharmaceutical Sciences, Tehran, Iran 2. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran,
3. Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences,
homogenizer. The pressure varied in the range of
The purpose of this study is to construct
300-1000 bar. The Z-average and zeta potential
was analyzed by Malvern Zetasizer ZEN 3600
formulation with skin targeting for topical
delivery of tretinoin which is important in
microscopy (TEM). Accelerated stability tests
reducing side effects of tretinoin in target site.
(Z-average, centrifuge, viscosity and …) were
Nanoemulsions consist in very fine emulsions,
done at 40 C and 75% humidity for 6 months.
with a droplet diameter smaller than 200nm.
They can be prepared by using a high shear and
Results and Discussion
high pressure devices, which allows a better
The property of the particles depends on the
control of the droplet size and a large choice of
amount of surfactant, production pressure and
the number of homogenization cycles. The best
formulation indicates z-average of 112.5 nm,
Pd.I of 0.137 and zeta potential of -45.95 mv.
Tretinoin has been increasingly at the center
This formulation is stable for 6 months during
of attention because of its efficiency in topical
healing of acne vulgaris, ichtyosis, psoriasis, and
neoplasia. Leads to local irritation such as erythema and flaking at the application site and increased weakness to sunlight it is observed limited tolerability by consumers. In this study we developed nano-emulsions as an alternative carrier system to usual emulsions and gels in order to make the possibility of controlled drug release, drug targeting, and reduce the local side effects of tretinoin.
Figure 1. TEM image of best formulation.
Materials and Methods
We formulated NE with nonionic surfactant
and high pressure homogenization technique
(HPH). For all formulations the lipid phase was
fabricated by HPH method is stable. Also this
method has a good potential to scale up simply in
surfactant at 75 C and a premix was formed by
pharmaceutical industries. We suggest this novel
homogenizing in an IKA Ultra Turrax T25 high-
drug delivery system for topical delivery of
speed stirrer. The premix was passed through an
tretinoin with more advantages than conventional
1. Lipid nanoparticles (SLN, NLC) in
cosmetic and pharmaceutical dermal products.
2009 (366): 170–184.
2. Saman Ahmad Nasrollahi, Alireza Abbasian,
Effat Sadat Farboud: Invitro comparison of
simple tretinoin-cream and cream loaded with
tretinoin-SLN. J. Pharm. Tech. Drug Res., 2013
3. Hamid Reza Kelidari, Jafar Akbari, Majid
Saeedi: Application and Characterization of
Solid Lipid Nanoparticles and Nanostructured
Lipid Carriers as Drug Delivery Systems. J.
Mazand. Univ. Med. Sci., 2013 (23): 387-403.
Chiara Noli DVM, DipECVD INTRODUCTION Dr Chiara Noli graduated atthe University of Milan in Leishmaniasis is a disease of human beings and animals causedby the protozoan parasite of the genus Leishmania . Dogs usuallydevelop the systemic (visceral) form of infection, with a highlyvariable clinical appearance. Canine leishmaniasis may be difficult todiagnose and frustrating to tr
UNIVERSIDAD AUTÓNOMA DE BUCARAMANGA FACULTAD DE CIENCIAS DE LA SALUD PROGRAMA ENFERMERIA FORMATO GUÍA DE CÁTEDRA 1. Identificación del curso 1.1 Escuela / Departamento: 1.2 Código: 1.3 Programa: ENFERMERIA 1.4 Código: ENFE 1.5 Carrera: ENFERMERIA 1.6 Código : ENFE 1.7 Nivel: PREGRADO 1.8 Curso: ENFERMERIA MATERNO INFANTIL 1.9 Código : ENFE