Linco-sol ump msds f
( L i n c o m y c i n h y d r o c h l o r i d e B P
i n U M P® M i c r o g r an u l ate f o r m )
Validity of MSDS: from 07/03/08
Statement of Hazardous Nature:
Not classified as hazardous according to criteria of Worksafe Australia.
L i n c o - s o l U M P ® Water soluble Microgranules
Lincomycin hydrochloride BP i n p r otected UMP® form
Dangerous Goods Class:
LINCO-SOL UMP is a water-soluble medication for the treatment of swine dysentery caused by Serpulina hyodysenteriae in pigs.
2. Physical Description/Properties
Weight per ml:
Not applicable Other Properties:
3. Information on Composition and Ingredients
4. Hazard Identification
Chronic Effects on Health:
Over exposure may cause skin, eye and upper respiratory
tract irritation or allergic reactions. Repeated over exposure to Lincomycin hydrochloride may cause abdominal cramps, diarrhoea and colitis. This may begin several weeks after exposure has ceased.
Repeated exposure may cause nausea, abdominal cramps, Diarrhoea and colitis, which may begin several weeks after exposure has ceased. Hyper sensitivity reactions have been reported in people known to be sensitive to penicillin.
Effects mucous membrane, causes soreness of mouth, nausea, diarrhoea
May be harmful to the eyes. Risk of irritation
Dust may irritate upper respiratory system and allergy.
5. First Aid measures
If poisoning occurs, contact doctor or Poisons Information Centre. Phone 131 126 Swallowed:
If in eyes, hold eyes open, flood with water for at least 15 minutes and see a doctor.
If skin contact occurs, remove contaminated clothing and wash skin thoroughly. Wash clothing before re-use.
Remove from exposure, rest and keep warm. In severe cases, obtain medical attention.
First Aid Facilities:
Advice for Doctor:
Treat hypersensitivity reactions as indicated clinically. Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular-blocking agents. if an allergic reaction should occur, the usual agents (epinephrine, corticosteroids, antihistamines) should be used as indicated.
6. Precautions for Use
Dox-al Australia Pty. Ltd. exposure limit – TWA: 0.2 mg/M3
Ensure adequate ventilation (same as outdoors) when using. If handling industrial quantities, or if dust risk exists, consider local mechanical exhaust/extraction to keep airborne contamination as low as possible.
Avoid contact with skin and eyes. Avoid breathing dusts. Personal protection to be selected from those recommended below, as appropriate to mode of use, quantity handled and degree of hazard:
Eye/face protection. Gloves - rubber or plastic.
Dust mask. Face shield or safety glasses. Gloves - rubber or plastic. Impervious overalls.
7. Handling and Storage
Correct Shipping Name:
Store below 25°C (Air Conditioning) in a cool dry place. Protect from light. Keep open packs tightly sealed.
8. Accidental release measures
Spills and Disposal:
Shake and empty contents into medicated water. Do not dispose of undiluted chemicals on site. Break, crush or puncture and bury empty containers in a local authority landfill. If no landfill is available, bury the containers below 500mm in a disposal pit specifically marked and set up for this purpose, clear of waterways, vegetation and roots. Empty containers should not be burned.
Not considered a fire hazard. May burn, or smoulder, in a fire. Not an explosion hazard.
Carbon dioxide, water vapour, black smoke, oxides of nitrogen, oxides of sulphur, zinc oxide fume. Incomplete
combustion may generate carbon monoxide.
In case of small fire/explosion:
Water fog or fine water spray, foam or Carbon Dioxide Danger of violent reaction
Breathing apparatus and protective gloves for fire only.
Prevent dissolved spillages from entering drains, natural waters or the environment.
9. Fire fighting Measures
Wear self-contained breathing apparatus and full body protective equipment.
May produce hazardous combustion products such as carbon monoxide, carbon dioxide,
oxides of nitrogen and sulphur, hydrochloric acid.
Extinguish using water, carbon, dioxide or dry chemical powder.
10. Stability and Reactivity
Conditions of Instability:
Incompatibility with various
Special Remarks on Reactivity:
Special Remarks on Corrosivity:
11. Exposure Controls / Personal Protection
None assigned by Worksafe Australia. Dox-al
Australia suggest limit: 0.2mg/cubic meter.
When mixing and handling, use protective clothing, impervious gloves, and dust respirator. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs,
immediately rinse with plenty of water. Respiratory Protection: Use an approved respirator.
12. Toxicological Information
No adverse effect 96 hour rainbow trout 980mg/litre; no adverse effect 96 hour bluegill 980mg/litre; no adverse effect 48 hour daphnia maga > 900mg/litre. (Concentrations refer to Lincomycin)
12. Toxicological Information continued
Lincomycin hydrochloride: LD50 (Rat, intravenous) 342mg/kg
LD50 (Rat, oral)
Spectinomycin sulfate tetrahydrate: LD50 (Rat, oral) > 5000mg/kg LD50 (Mouse, intravenous)
No teratogenic effects seen in rats or dogs
13. Ecological Information
PERSISTENCE IN SOIL AND WATER
Lincomycin hydrochloride can undergo hydrolysis at both acid and basic pH's at elevated
temperatures. However, in the pH range 3-6 at room temperature degradation is small.
Lincomycin bioactivity is readily degraded by mixtures or urine, faeces and soil. The half-life
of degradation was about 20 days. BIODEGRADABILITY
Lincomycin hydrochloride melts with decomposition at 148°C. It has no measurable vapour
pressure; therefore it is not expected to enter the air. Lincomycin hydrochloride is very
soluble in water (500-1000mg/ml) and undergoes hydrolysis at both acid and basic pH's at
elevated temperatures. Lincomycin can be absorbed into soil, but it is readily leached away
from soils. Lincomycin is expected to be relatively mobile and migrate toward the aquatic
Lincomycin has a low octanol-water partition coefficient at all pH's. The octanol-water
partition at pH 7 is 2.550. Calculated flowing and static bioaccumulation factors are 2.21 and
9.96, respectively. Lincomycin will be expected to migrate to the aqueous environment, but it
should not bioaccumulate in aquatic organisms.
Lincomycin will have some initial inhibitory effects on the most sensitive micro-organisms
until it is degraded. Small amounts sent to sanitary sewage will not adversely affect the flora
of sewage treatment facilities.
14. Disposal Considerations
- Shake and empty contents into medicated water.
- Keep out of drains.
- Prevent entry to surface water, groundwater and soil.
- Vacuum-clean or scoop spilt material and place in a container.
- Wash after handling and launder contaminated clothing before reuse.
- Dispose of empty containers by wrapping with paper and putting in garbage.
- Empty containers should not be burned. 15. Transport Information
No special transport requirements necessary. 16. Other Information
This Material Safety data Sheet (MSDS) has been prepared according to the Guidelines of
Worksafe Australia and the information is believed to be true and correct at the time of
publication. THIS MATERIAL SAFETY DATA SHEET SHALL NOT BE DEEMED TO CREATE ANY
WARRANTY OF ANY KIND (INCLUDING WARRANTY OF MERCHANTABLE QUALITY OR
FITNESS FOR A PARTICULAR PURPOSE) and is valid for 1 year.
If you require information on the product contact
If you are unable to contact Dox-al Australia, Call the Australian Poisons Centre on
131 126 (Australia)
This Material Safety data Sheet (MSDS) has been prepared according to the Guidelines of Worksafe
Australia and the information is believed to be true and correct at the time of publication and valid for 1
year. The information has been compiled from sources we believe to be reliable. It is offered as a guide
only for safe handling procedures and for safe use and storage. Dox-al Australia urges users of the
product to read the MSDS carefully and note all precautions when using this substance. Dust emitted
during handling of any chemical substance should be considered dangerous. To promote safe handling,
the user should notify its employees, customers and anyone who may come in contact with the material
or who may use the material either as a pure substance or in premix or stock feed of any health
warnings or risks associated with its use and contained in this MSDS. This safety data sheet is not
intended to be a substitute for consultation with appropriately trained personnel. As use of the product
is outside the control of the manufacturer, the user assumes all responsibility for safe use and handling
of the product. It is the responsibility of the user to ensure safe working conditions and that the product
is suitable for the application for which it is purchased and to be used.
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