If the client is on ANY of these drugs OR has any of the health conditions listed, consult a MD.
If there are concerns re: interactions with any drug not listed, consult a Pharmacist/HIV Expert.
CONTRAINDICATED Use with CAUTION
Antiarrhythmics ▪ Flecainide (Tambocor®)
Antiarrhythmics ▪ Amiodarone (Cordarone®)
Antibiotics ▪ Rifampin (Rifadin®, Rofact®)
Antihistamines ▪ Astemizole (Hismanol®)
Antibiotics ▪ Clarithromycin (Biaxin®)
Ergot Derivatives ▪ Bellergal Spacetabs®
Anticonvulsant ▪ Carbamazepine (Tegretol®)
Antifungals ▪ Itraconazole (Sporanox®)
GI Mortality Agents ▪ Cisapride (Propulsid®)3
Herbal Products ▪ St. John’s Wort (Hypericum perforatum)
Calcium Channel Blockers ▪ Felodipine (Plendil/Renedil®)
▪ Nicardipine (Cardene®)▪ Nifedipine (Adalat®)
Corticosteroids ▪ Dexamethasone (Decadron®)
Immunosuppressants ▪ Cyclosporine (Neoral®, Sandimmune®)
Inhaled Steroids ▪ Fluticasone (Flonase®, Advair®)
PDE5 Inhibitors ▪ Sildenafil (Viagra®)
▪ Tadalafil (e.g., Cialis®)▪ Vardenafil (Levitra®)
Oral/Patch Contraceptive ▪ Norethindrone
Statins ▪ Atorvastatin (Lipitor®) or Rosuvastatin
1 History of hepatitis does not rule out HIV PEP. MD and/or HIV Expert consultation recommended. Possible contraindication in the event of acute symptomatic illness or
severely elevated liver enzymes (> 5X normal). Dosage adjustments may be necessary.
2 Not all drugs within each drug class are contraindiated - only drugs listed above are contraindicated when co-administered with either Combivir® or Kaletra®. 3 Product no longer available in Canada, only available in the United States. 4 If it is suspected that the client is emotionally unstable and/or at risk of overdosing, it is recommended to use Combivir® alone.
If the client is on ANY of these drugs OR has any of the health conditions listed, consult a MD.
If there are concerns re: interactions with any drug not listed, consult a Pharmacist/HIV Expert.
CONTRAINDICATED Use with CAUTION
Health Abnromally low neutrophil count (< 0.75 x 109/L)
ir® Conditions Abnormally low hemoglobin levels (< 75 g/L)
Pancreatitis (history OR risk factors) 5Kidney problems
▪ Trimethoprim-sulfamethoxazole (Septra®)
b Precautions
▪ Amphotericin B▪ Fluconazole (Diflucan®)
▪ Stavudine (Zerit®)▪ Zalcitabine (Hivid®)
▪ Interferon alpha (Roferon®-A, Intron® A,
1 History of hepatitis does not rule out HIV PEP. MD and/or HIV Expert consultation recommended. Possible contraindication in the event of acute symptomatic illness or
severely elevated liver enzymes (> 5X normal). Dosage adjustments may be necessary.
2 Not all drugs within each drug class are contraindiated - only drugs listed above are contraindicated when co-administered with either Combivir® or Kaletra®. 3 Product no longer available in Canada, only available in the United States. 4 If it is suspected that the client is emotionally unstable and/or at risk of overdosing, it is recommended to use Combivir® alone. 5 Increased concern in paediatric clients.
Non-essential medications, alternate therapy, vitamins and recreational drug use should be discontinued during the HIV PEP regimen (e.g., herbal mood enhancers/sleep aids such as 5-hydroxy-L-triptophan (5HTP or Tryptophan); multi-vitamins).
Kaletra® can decrease the effectiveness of long-term use birth control pills. Barrier form contraceptive (e.g., condom) should be used for 28 days + 2 months.
The use of Combivir® and Kaletra® during pregnancy has not been extensively studied. IF a woman is pregnant: HIV PEP drugs are potentially teratogenic in the 1st trimester (often avoided during this period).
Since Kaletra is a substrate and potent CYP3A4 inhibitor, caution should be used when co-administering Kaletra and CYP3A4 enzyme inducers, inhibitors, or substrates with narrow therapeutic indices. If in doubt, please consult with an HIV Expert or Pharmacist.
STOP HIV PEP if: Grade 4 AE; Hemoglobin <80 g/L; Absolute Neutrophil < 0.5 x 109/L; Platelet Count <20,000 cells/µL; AST / ALT / ALP / Bilirubin > 5X upper limit of normal.
PERUBAHAN ATAS PERATURAN PEMERINTAH NOMOR 13 TAHUN 1999 TENTANG PENGELOLAAN LIMBAH BAHAN BERBAHAYA DAN BERACUN Menimbang : a. bahwa lingkungan hidup perlu dijaga kelestariannya sehingga tetap mampu menunjang pelaksanaan pembangunan yang berkelanjutan; b. bahwa dengan meningkatnya pembangunan di segala bidang, khususnya pembangunan di bidang industri, semakin meningkat pula jumlah limbah y
• The early days of the minipig • The reasons why minipigs came to be • Examples of safety pharmacology studies • Regulatory acceptability • For many years the standard approach has been to use a rodent and a non-rodent for safety assessments. – MICE: single & repeat dose studies, carcinogenicity. – RATS: single & repeat dose studies, reproductive – RABBITS: dermal stu
If the client is on ANY of these drugs OR has any of the health conditions listed, consult a MD. 
If the client is on ANY of these drugs OR has any of the health conditions listed, consult a MD.