Steve_kagen-cv

STEVE KAGEN, M.D.
HIGHLIGHTS
• Winner Environmental Protection Agency's 2005 Children's Environmental Health Recognition Award for creating The Allergy Family® Guide 5th grade educational program • Voted by Wisconsin physicians as one of “Best Doctors in America” • Chairman of Allergen Standardization Committee of the American Academy of Allergy, Asthma, and Immunology • Director Certified Diagnostic Allergy - Immunology Lab (AllerLab®) • Elected U.S. House of Representatives in 2006 and 2008 – WI District 8. ALLERGY RESEARCH
• U.S. Patent for the discovery of worldwide Dust Mite Allergen • Standardized vaccine treatments for Allergen Immunotherapy • Developed new Venom Immunotherapy technique for Bee Sting Allergy • Discovered and sequenced Insect Allergens • First in the World to Clone and Express an allergenic protein in bacteria • Only clinic in America with polymerized ragweed and grass vaccines proven to be the safest allergy injection • Discovered allergens in frog, buckwheat, eggplant, almond, and spices • Discovered Cross-Reactive Allergens between foods and rubber latex • Proved Helicobacter pylori may cause Hives • Discovered a possible cause of Crohn's Disease (Copepods) • Demonstrated Mite vaccines do not contain Prion proteins • Daily Pollen and Mold Spore Monitoring of NE Wisconsin (1992 – 2013) CURRICULUM VITAE
U.S. CITIZEN!
EDUCATION
Undergraduate!
Medical School !
University of Wisconsin School of Medicine Internship & Residency !
Northwestern University School of Medicine Fellowship!
BOARD CERTIFICATION
American Board of Allergy & Immunology ! UNIVERSITY AFFILIATIONS
Division of Allergy & Clinical Immunology PROFESSIONAL SOCIETIES
Fellow, American Academy of Allergy, Asthma & Immunology Fellow, American College of Allergy, Asthma & Immunology ALLERGY-IMMUNOLOGY SPECIALTY COMMITTEES
American Academy of Allergy, Asthma & Immunology: Insect Allergy Committee Latex Allergy Committee Allergen Standardization Committee, Chairman BOARD OF DIRECTORS
Joint Council of Allergy, Asthma and Immunology 1988-1992 PROJECTS
Author and Project Director “Helpful Hints” on Kleenex Packages Author, Project Director Allergy Relief Guide A national pollen and mold information service with distributions to television and print media Aeroallergen Animations: computer animations of North American pollens and mold spores. An interactive educational 5th grade school program about allergies and asthma. The Aeroallergen PhotoLibrary™ of North America Interactive CD and website-based audio and slide program focused on airborne allergens.
U.S. PATENT: DUST MITE ALLEGEN
U.S. patent awarded to Steven L. Kagen, M.D. and R. Muthiah, PhD for discovery of major allergen in the dust mite, L. destructor. U.S. Patent No. 5,236,834, Allergenic Molecules from Lepidoglyphus Destructor. Worldwide FOX CITIES CHILDREN’S MUSEUM
Creative developer of The Allergy Arcade™ in Appleton, Wisconsin – an interactive educational exhibit designed to teach children and parents about the world of allergy and asthma. CNN ALLERGY CONSULTANT
Exclusive source of daily allergy information to CNN from 1995 to 2002. THE WEATHER CHANNEL
Dr. Kagen provided daily national pollen and mold graphics to The Weather Channel, educating the public about the importance of aeroallergens as causes of asthma, sinus headaches, and hay fever. ALLERNET.COM
Creator and owner of Allernet.com® - a website designed to provide the general public with useful allergy and asthma information along with referral services to Certified allergy specialists throughout the United States at: DISTINCTIONS
In 1988, Dr. Kagen became one of the first physicians in Wisconsin to be Board Certified in Diagnostic Laboratory BEST DOCTOR IN AMERICA
Voted by Wisconsin physicians as one of the “Best Doctors in America” 1996 Founder's Award Fox Cities Children's Museum 2004 Community Outreach Award from the American Academy of Allergy, Asthma and Immunology for The Allergy Family Guide® - a 5th grade allergy and asthma education program. Environmental Protection Agency’s 2005 Children’s Environmental Health Recognition Award for The Allergy Family Guide, for “protecting children from environmental risks, fundamental to making the world a healthier place, now and for future generations.” 2005 Abstract of Distinction at Federation of Clinical Immunology Societies for “Superior safety of polymerized allergen vaccines: Zero systemic reactions during 55,000 injections of polymerized ragweed and grass vaccines in The Aeroallergen PhotoLibrary of North America.
Steve Kagen, M.D., Walter Lewis, PhD and Estelle Levetin, PhD. 2004 Allergy InsideOut® Steve Kagen, M.D. 2004 The Allergy Family® Guide Steve Kagen, M.D. 2004 SCIENTIFIC PUBLICATIONS
1. Soluble mediators of cellular immunity: partial characterization of Blastogenic Factor. Honors Thesis, 2. Kagen SL, Fink JN, Sohnle P and Kurup VP. Marijuana smoking as a source of Aspergillus exposure. In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March 1981, San Francisco, 3. Kagen SL, Sohnle P, Kurup VP and Fink JN. Aspergillus: An inhalable contaminant of marijuana. New England Journal of Medicine. 1981;304:483-84. 4. Kagen SL, Fink JN, Schlueter DP, et al. Anti-Induced Asthma static agent as a cause of small airway disease. In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March, 1981, San Francisco, 5. Kagen SL, Fink JN, Schlueter DP, Kurup VP, Pneumonitis and Fruchtman R. Streptomyces albus: A new cause of hypersensitivity pneumonitis. J Allergy Clin Immunol. 1981;68:295-99. 6. Kagen SL, Cohen SH and Kurup VP. Ketoconazole therapy of allergic bronchopulmonary aspergillosis. Presented at the International Congress of Allergology and Clinical Immunology. London, England, 1982. 7. Cohen SH and Kagen SL. Cimetidine and allergy skin testing. Annals of Internal Med. 1981;96:787. 8. Kagen SL, Schlueter DP, Cohen SH. Induction of small airways disease by a fabric softener. 9. Kagen SL, Kurup VP, Sohnle PG, and Fink JN. Marijuana smoking and fungal sensitization, J Allergy Clin 10. Kurup VP, Resnick A, Kagen SL, Cohen SH and Fink JN. Allergic fungi and actinomycetes in smoking materials and their health implications. Mycopathologia. 1983;82:61-4. 11. Nunnink JC, Wiedmeyer J, Hank J, Kagen SL and Sondel PS. Characterization of a possible suppressive factor in AIDS. UCLA AIDS Symposium, Salt Lake City, Utah, 1983. 12. Kagen SL, Yunginger J, and Johnson R. Lake fly allergy: Incidence of chironomid sensitivity in an atopic population. In Proceedings of the 40th Annual Meeting of the American Academy of Allergy & Immunology, 13. Kagen SL. Inhalant insect allergy. In Monograph on Insect Allergy, 1986; pp 93-102. (Levine MI and Lockey RF Eds) D. Lambert Associates, Pittsburgh, PA. Occupational Insect Allergy & Asthma 14. Kagen SL, Yunginger J and Wynn SR. Occupational respiratory allergy due to caddisfly aeroallergens. J 15. Kagen SL, Yunginger J, Wynn SR and Swanson MC. Midge-specific IgE and IgG responses during lake fly desensitization: An open trial. J Allergy Clin Immunol. 1986;77:140. 16. Kagen SL. Inhalant allergy to arthropods: Insects, arachnids, and crustaceans. Clin Rev Allergy.1990; 17. Kagen SL, Koshte V, and Aalberse R. Cross-reactivity of caddisfly-specific IgE antibodies with arthropoda and mollusca. Allergy Proceedings. 1988;9:289. 18. Koshte VL, Kagen SL and Aalberse R. Cross-reactivity of IgE antibodies to caddisfly with arthropoda and mollusca. J Allergy Clin Immunol. 84:174-83, 1989. 19. Kagen SL and Siebert P. Cloning of insect aeroallergens: midge hemoglobins. Allergy Proceedings. 20. Bernstein D, Mittman RJ, Kagen SL, Korbe BS and Bernstein IL. Safety and efficacy of rapid venom immunotherapy (RVIT) for treatment of Hymenoptera-sensitive patients. J Allergy Clin Immunol. 1989;83:227. 21. Kagen SL and Muthiah R. Fire ant anaphylaxis: Allergen characterization and partial amino acid sequence of Sol i II and Sol i III. Ann Allergy. 1990;64:75.
Guidelines for Diagnosis of Occupational Lung Disease 22. Bush R and Kagen SL. Guidelines for the preparation and characterization of high molecular weight allergens used for the diagnosis of occupational lung disease. J Allergy Clin Immunol. 1989;84:814-19. 23. Bernstein D, Mittman RJ, Kagen SL, Korbee L, Enrione M and Bernstein IL. Clinical and immunologic studies of rapid venom immunotherapy in Hymenoptera-sensitive patients. J Allergy Clin Immunol. 1989;84:951-59. 24. Muthiah R and Kagen SL. Food Allergens: Characterization of major buckwheat carbohydrate dependent allergens. J Allergy Clin Immunol. 1990;85:151. 25. Kagen SL and Muthiah R. Insect allergens: Characterization and partial sequencing of a caddisfly hemoglobin. J Allergy Clin Immunol. 1990;85:152. 26. Muthiah R and Kagen SL. Allergens as enzymes: Degradation of cat and ragweed allergens by house dust mite allergen extract. J Allergy Clin Immunol.1990;85:151. 27. Kagen SL, Isaacson B and Muthiah R. Polymerized ragweed vaccine: Retention of all epitopes. J Allergy Clin 28. Knoll R, Kagen SL and Muthiah R. Allergens as enzymes: Failure of HSA to protect degradation of grass allergens by mold extracts. J Allergy Clin Immunol. 1991;87:188. 29. Muthiah R, Miller M and Kagen SL. Barn allergy: Isolation and characterization of the major allergens of storage mites: L. destructor. J Allergy Clin Immunol. 1991;87:326. 30. Baur X, Liebers V, Mazur G, Becker WM, Kagen SL, Kawai K. Immunologic cross-reactivity of hemoglobins in the Diptera family Chironomidae. Allergy 1991;46:445051. 31. Knoll R, Kagen S and Muthiah R. Non-specific reactivity of fire ant whole body extract in the diagnosis of fire ant allergy. J Allergy Clin Immunol. 1992;89:51. 32. Muthiah R, Kagen S, Hildeman D and Knoll R. New Immunization screen reveals under-immunization of patients attending allergy & asthma clinics. J Allergy Clin Immunol. 1992;89:490. 33. Kagen S, Muthiah R, Hildeman D, Knoll R and Friedman S. Fire ant anaphylaxis: Initial determination of fire ant-specific IgG antitoxin levels. J Allergy Clin Immunol. 1992;89:716. 34. Kagen SL. Other indications for administration of allergy immunotherapy: Insects, fire ants and therapeutic agents. Immunology and Allergy Clinics of North America. 1992;12:177-97. 35. Bernstein JA, Kagen SL, Bernstein DI and Bernstein IL. An extended experience indicating that rapid venom immunotherapy (RVIT) is safe for treatment of Hymenoptera (Hym) anaphylaxis. J Allergy Clin Immunol. Polymerized Midge Allergen Immunotherapy 36. Knoll R, Kagen SL, Muthiah R and Hildeman. Polymerized midge allergen immunotherapy (PMAIT): clinical reduction in early and late phase reactivity and prevention of rhinitis and asthma morbidity. J Allergy Clin Polymerized Grass Allergen Immunotherapy 37. Hildeman D, Muthiah R and Kagen SL. Successful polymerized grass allergen immunotherapy (PGAIT): failure of in vitro measurements to correlate with clinical outcomes. J Allergy Clin Immunol. 1994;93:251. Polymerized Ragweed Allergen Immunotherapy 38. Hempel D, Muthiah R, Hildeman D and Kagen SL. Polymerized ragweed allergen immunotherapy (PRAIT): failure of anti-idiotypic antibody (AIA) to predict clinical outcomes. J Allergy Clin Immunol. 1994;93:251. 39. Zondlo J, Muthiah R, Knoll R and Kagen SL. Helicobacter pylori (Hp): a new cause of urticaria (U) and exercise-induced anaphylaxis (EIA) -identification of Hp allergens. J Allergy Clin Immunol. 1994;93:220. 40. Kagen SL, Muthiah R and Knoll R. Allergens as enzymes: a two-year study of aqueous allergen extract stability and the deleterious effect of mixing allergen extracts together. J Allergy Clin Immunol. 1994;93:253. 41. Muthiah R, Kagen SL and Hempel D. Frog-induced anaphylaxis (ANA): isolation and characterization of the major frog allergen, which is cross-reactive with cod parvalbumin. J Allergy Clin Immunol. 1994;93:209. 42. Bernstein JA, Kagen SL, Bernstein DI and Bernstein LB. Rapid venom immunotherapy is safe for routine use in the treatment of patients with Hymenoptera anaphylaxis. Annals of Allergy Asthma Immunol. 43. Muthiah R, Louthain L, Knoll R and Kagen S. Flaxseed-induced anaphylaxis: another cross-reactive carbohydrate food allergen. J Allergy Clinic Immunol. 1995;95:370. 44. Kagen S, Zondlo A, Zondlo J and Muthiah R. Helicobacter pylori and allergic disease: characterization of Helicobacter allergens. J Allergy Clin Immunol. 1995;95:255. 45. Kagen SL and Chapman M. Allergy to inhalants of arthropods: insects and arachnids. In Monograph on Insect Allergy. 1995;95:370. (Levine MI and Lockey RF Eds). D. Lambert Associates, Pittsburgh, PA. 46. Muthiah R, Zondlo A, Zondlo J and Kagen S. Eggplant anaphylaxis: isolation of the major allergens and demonstration of cross-reactivity with other Solanaceae. J Allergy Clin Immunol. 1996;97:334. 47. Kagen S, Muthiah R, Knoll R, Graphos G and DeStasio B. Aerobiology: Grass pollen forecasting models. J 48. Kagen S, Muthiah R and Slupianek J. Mannose binding protein deficiency is more frequent than IgA deficiency. J Allergy Clin Immunol. 1997;99:S396 49. Muthiah R, Kagen S, Zondlo A and Zondlo J. Hidden allergens in medications: Allergy to acacia in Synthroid tablets. J Allergy Clin Immunol. 1997;99:S492. 50. Kagen SL and Muthiah R. Latex and Food induced Anaphylaxis: Oregano, Dill, Sage and Carrot Cross-React with Natural Rubber Latex. J Allergy Clin Immunol. 1998;101:S208. 51. Muthiah R, Yablon B, Reddy, and Kagen S. Chinchilla Allergy: A new Cause of Animal Hypersensitivity. J 52. Kagen S and Muthiah R. Anaphylaxis to PPD: Tuberculosis Skin Test Antigen Atopy. J Allergy Clin Immunol. 53. Kagen SL and Muthiah R. Latex, Almond and Tobacco: Cross-Reactive Allergens. Annals Allergy, Asthma 54. Muthiah R, Peterson A and Kagen SL. Latex and Ginger Allergy. Annals Allergy, Asthma Immunol 55. Kagen SL and Muthiah R. Ladybugs: A New Cause of Allergy. Annals Allergy, Asthma Immunol. 2000;84:146. 56. Muthiah R, Ptachinski K, Ludden D, Kagen SL Insect Allergens: Isolation of Caddisfly Allergens. J Allergy Clin 57. Zondlo J, Muthiah R, Kagen S and Kagen M. Kombu Induced Anaphylaxis. Annals Allergy Asthma Immunol. 58. Muthiah R and Kagen S. Ragweed Pollen in the Spring Air. Annals Allergy Asthma Immunol. 2003;90:115. 59. Muthiah R, Arlian L and Kagen S. Leaf Mites: Viable Sources of Outdoor Aeroallergens. Annals of Allergy. 60. Muthiah R and Kagen S. Ladybug Allergy: Sequence of a Major Asian Beetle Allergen. Annals of Allergy 61. Kagen S, Muthiah R and Breteler K. Copepods: A New Worldwide Source of Allergens. Annals of Allergy 62. Muthiah R and Kagen S. Anaphylaxis induced by Slim- Fast: The perils of weight lost in two patients. Annals 63. Kagen S and Muthiah R. Poisonous Snake Venom Anaphylaxis vaccination: A case report of a non-physician directed experiment. Annals of Allergy Asthma Immunol. 2004;92:72. 64. Gutin F, Kagen S, Muthiah R, Bahrainwala A. Severe protracted anaphylaxis to midge allergen in a 4 YO boy. Annals of Allergy Asthma Immunol. 2004;92:P171. 65. 65. Kagen S, Muthiah R, Holinbeck J. A new and safer method for preserving allergen stability in human vaccines. J Allergy Clin Immunol. 2004;113;S110P. 66. Kagen S, O’Rourke K, Muthiah R, and Arlian LG. Prion proteins in vaccines intended for human use - mites, human serum albumin and mite colony feeds: No evidence of prion presence. Annals of Allergy Asthma 67. Kagen S and Muthiah R. Anaphylaxis associated with eating a Breakfast Square product. Partial Sequences of Copepod-Derived Protein Antigens 68. Muthiah R, Kagen S and Burton RS. Copepods: Worldwide sources of allergens - partial sequences of three unique proteins. J Allergy Clin Immunol 2005; 115:S91. Superior Safety of Polymerized Allergen Vaccines 69. Kagen S, Zondlo J, Muthiah R and Kagen M. Superior safety of polymerized allergen vaccines: Zero systemic reactions during 55,000 injections of polymerized ragweed and grass vaccines in 500 allergy patients. 2005. 70. Focalin inhibits allergen and histamine skin testing. Kagen M, Nayeri Z and Kagen S. J Allergy Clin Immunol.

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