Interpretation of skindex-29 scores: cutoffs for mild, moderate, and severe impairment of health-related quality of life
cytes via transcriptional control of the Akt1
The authors state no conflict of interest.
Jiang YJ, Lu B, Kim P et al. (2008) PPAR and LXR
We thank Ms Aoyanagi for her technical assistance.
This work was supported in part by a grant-in-aid
Mitsutake S, Suzuki C, Akiyama M et al. (2010)
from the Ministry of Education, Science, Sports and
glucosylceramide accumulation during kerati-
Culture of Japan (Kiban A 23249058: to MA), a grantfrom the Ministry of Health, Labor and Welfare of
nocyte differentiation. J Dermatol Sci 60:128–9
Japan (Health and Labor Sciences Research Grants;
Moskowitz DG, Fowler AJ, Heyman MB et al.
Research on Intractable Disease: H22-177: to MA),
and a grant-in-aid from the Japan Society for the
failure in children with ichthyosis: an evalua-
Promotion of Science Fellows (to TY).
tion of cutaneous ultrastructure, epidermalpermeability barrier function, and energy
Ganglioside loss promotes survival primarily
without phosphoinositide 3-OH kinase sig-naling. J Invest Dermatol 119:107–17
significantly higher than that from wild-
Thrash BR, Menges CW, Pierce RH et al. (2006)
Sapporo, Japan; 2Department of Dermatology,Nagoya University Graduate School of
AKT1 provides an essential survival signal
required for differentiation and stratification
Translational Pathology, Hokkaido University
of primary human keratinocytes. J Biol Chem
Graduate School of Medicine, Sapporo, Japan
Hydrolytic pathway protects against cera-
Department of Pathology, Hokkaido UniversityGraduate School of Medicine, Sapporo, Japan
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Interpretation of Skindex-29 Scores: Cutoffs for Mild, Moderate,and Severe Impairment of Health-Related Quality of Life
Journal of Investigative Dermatology (2011) 131, 1945–1947; published online 19 May 2011
scores correctly. What does a given score
really mean? Although there is no standard
important challenge is to interpret these
approach, several methods exist to facil-itate the interpretation of HRQL scores.
Abbreviation: HRQL, health-related quality of life
CAC Prinsen et al.
Interpretation of Skindex-29 Scores
Table 1. Skindex-291 cutoff scores for mildly, moderately, and severely impaired HRQL
Impact of disease on HRQL for Skindex-29 domain andoverall scores2
Abbreviations: AUC, area under the curve; HRQL, health-related quality of life.
1The domain scores and the overall score are expressed on a 100-point scale, with higher scores indicating a lower level of quality of life.
2The number of patients in each severity category varies, as it largely depends on the required number of responses to the Skindex-29 domains. The numberof patients with mildly impaired HRQL ranged from 144–195; the number of patients with moderately impaired HRQL ranged from 73–104; and the numberof patients with severely impaired HRQL ranged from 49–74.
3AUC: 0.50 indicates chance categorization and 1.00 indicates perfect categorization of a given Skindex-29 score to correctly classify mild, moderate, orsevere impairment of HRQL.
4Cutoff scores and AUC coefficients for severely impaired HRQL as presented in the original article
receiver-operating characteristic statis-
of effect. In this letter, we will provide
Skindex-29 domain score (r ¼ 0.54).
practice, it might be helpful, as a rule of
meanings of ‘‘symptoms’’ as worded in
ment to measure psychiatric morbidity.
the anchor question and ‘‘symptoms’’
overall scores, with the exception of the
1946 Journal of Investigative Dermatology (2011), Volume 131
Infliximab Infusions for Netherton Syndrome
The authors state no conflict of interest.
Chren MM (2010) Interpretation of quality-of-life
The original study was performed in nine derma-tology outpatient clinics in the Netherlands.
Guyatt GH, Osoba D, Wu AW et al. (2002) Methods
We thank all the dermatologists whose collabora-
to explain the clinical significance of health
status measures. Mayo Clin Proc 77:371–83
Chren MM, Lasek RJ, Flocke SA et al. (1997a)
Nijsten T, Sampogna F, Abeni D (2009) Categori-
zation of Skindex-29 scores using mixture
capability of a refined version of Skindex,a quality-of-life instrument for patients
Prinsen CA, Lindeboom R, Sprangers MA et al.
(2010) Health-related quality of life assess-
Amsterdam, The Netherlands and 2Department
Chren MM, Lasek RJ, Quinn LM et al. (1997b)
ment in dermatology: interpretation of Skin-
of Clinical Epidemiology, Biostatistics and
dex-29 scores using patient-based anchors.
of a generic and a disease-specific instrument
Infliximab Infusions for Netherton Syndrome: SustainedClinical Improvement Correlates with a Reduction ofThymic Stromal Lymphopoietin Levels in the Skin
Journal of Investigative Dermatology (2011) 131, 1947–1950; published online 9 June 2011
for an extensive pruritic dermatitis that
tration and contributing to atopy in NS.
titis–like lesions and elevated serum IgE
could reduce skin inflammation in NS.
12, thus confirming the diagnosis of NS.
the institutional ethical requirements of
the superficial dermis, whereas thedensity of mast cells was similar to thatin normal skin. Because TNF-a is
Abbreviations: LEKT1, lymphoepithelial Kazal-type-related inhibitor; NS, Netherton syndrome; SPINK5,
serine protease inhibitor Kazal-type 5; Th2, T helper type 2; TNF-a, tumor necrosis factor-a; TSLP, thymic
Federal Bureau of Investigation Color of Law - Civil Application Request for Investigation and Remedies for Violations of Title 42, U.S.C., Section 14141 (Police Misconduct Statute) This application is a formal request for the Department of Justice to seek civil remedies due to policies and practices that foster a pattern of misconduct by employees of the Los Angeles Police Dep
“¿Por qué los alemanes son como son?” Alemania desde dentro En colaboración con el Barcelona Centre for International Affairs (CIDOB) Jueves, 24 de octubre y viernes, 25 de octubre 2013 Jueves, 24 de octubre de 2013 Introducción y bienvenida CARLES A. GASÒLIBA Presidente del CIDOB BERNHARD BRASACK Cónsul General de Alemania Alemania después de las el